Zinc finger protein ZIC 3 Antibodies

AND ZIC3 ELISA kits, Zinc finger protein ZIC 3 Proteins

Many biological assays use antibodies to detect Zinc finger protein ZIC 3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Zinc finger protein ZIC 3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Zinc finger protein ZIC 3 antibodies...

We validate the specificity of these antibodies to Zinc finger protein ZIC 3 by testing them on tissues known to express ZIC3 positively and negatively. Browse below to find the ZIC3 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ZIC3 Infographic by Boster Bio

All ZIC3 Products

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Specificity

Applications

Price

Anti-ZIC3 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A04050-2
100 μg/vial

Anti-ZIC3 Mouse Monoclonal Antibody [Clone ID: OTI1G7]

Human, Mouse

$523
Cat # M04050
100 µl

ZIC3 (NM_003413) Human Over-expression Lysate

Human

$960
Cat # LS007547
100 µg

ZIC3 Overview

Facts about Zinc finger protein ZIC 3.

ZIC3 3D structure. Source: alphafold

Zinc finger protein ZIC 3 (ZIC3)

Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification.

Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. .

Gene Information

Human
Gene Name:	ZIC3
Uniprot:	O60481
Entrez:	7547

Family

Belongs to:

GLI C2H2-type zinc-finger protein family

Alternative Names

Heterotaxy 1; HTX1; HTXHTX1; Zic family member 3 (odd-paired homolog, Drosophila); ZIC3; Zinc finger protein 203; zinc finger protein ZIC 3; ZNF203; ZNF203Zinc finger protein of the cerebellum 3

Molecular Weight

Mass (kDA):
50.569 kDA

Genomic Context


Human

Location:	Xq26.3
Sequence:	X; NC_000023.11 (137566127..137577691)

Subcellular Localizations

Nucleus. Cytoplasm. Localizes in the cytoplasm in presence of MDFIC overexpression (By similarity). Translocation to the nucleus requires KPNA1 or KPNA6.

Diseases

Situs Ambiguus
Congenital Abnormality
Congenital Heart Defects
Nervousness
Crest Syndrome
Heart Diseases
Situs Inversus
Heterotaxy Syndrome
Congenital Heart Disease
Genetic Diseases, X-linked
Dextrocardia
Transposition Of Great Vessels

Holoprosencephaly
Hyperplasia
Diabetes Mellitus
Hypoplasia
Neoplasms
Sex Chromosome Aberrations
Cytogenetic Abnormality

Pathways

Gastrulation
Localization
Pathogenesis
Neural Tube Closure
Transposition
Tube Closure
Cell Proliferation
Neurogenesis
Cell Cycle
Cell Differentiation
Segmentation
Somitogenesis
Transport

Nuclear Import
Methylation
Forebrain Development
Developmental Process
Nuclear Export
Limb Development
Nuclear Transport

PTMs

Methylation

Phosphorylation

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ZIC3

References

PMID: 9354794 by Gebbia M., et al. X-linked situs abnormalities result from mutations in ZIC3.

PMID: 19266028 by Salichs E., et al. Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment.