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- Table of Contents
Facts about Zinc finger protein ZFPM2.
Such heterodimer can both activate or repress transcriptional activity, depending upon the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY.
Mouse | |
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Gene Name: | Zfpm2 |
Uniprot: | Q8CCH7 |
Entrez: | 22762 |
Belongs to: |
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FOG (Friend of GATA) family |
transcription factor GATA4, modulator of; zinc finger protein 89B; zinc finger protein, multitype 2
Mass (kDA):
127.692 kDA
Mouse | |
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Location: | 15 B3.1|15 15.74 cM |
Sequence: | 15; |
Expressed in heart, brain and testis. Weakly expressed in lung and liver. First expressed at approximately E8.5 in the developing ventral heart tube and septum transversum. Cardiac expression persists throughout the remainder of embryonic development in the atria as well as in all layers of the ventricles (endocardium, myocardium, and pericardium). Expressed in the neuroepithelium of the developing midbrain and hindbrain from E11.5 and increased in intensity between E12 and E16.5. Also expressed in the urogenital ridge beginning at E11.5 and subsequently localized to the gonads by E16.5. Colocalizes with GATA4 GATA5 and GATA6 in the developing heart, GATA3 in the brain, and GATA4 in the gonads.
PMID: 9927675 by Svensson E.C., et al. Molecular cloning of FOG-2: a modulator of transcription factor GATA- 4 in cardiomyocytes.
PMID: 9927674 by Tevosian S.G., et al. FOG-2: a novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped.