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Zinc finger protein ZFPM1 Antibodies
AND Zfpm1 ELISA kits, Zinc finger protein ZFPM1 Proteins
Many biological assays use antibodies to detect Zinc finger protein ZFPM1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Zinc finger protein ZFPM1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Zinc finger protein ZFPM1 antibodies...
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Zfpm1 Overview
Facts about Zinc finger protein ZFPM1.
Zinc finger protein ZFPM1 (Zfpm1)
Transcription regulator that plays a vital role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3.
Such heterodimer can both activate or repress transcriptional activity, depending upon the cell and promoter context. The heterodimer formed with GATA proteins is vital to activate expression of genes like NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Zfpm1 |
| Uniprot: | O35615 |
| Entrez: | 22761 |
Family
| Belongs to: |
|---|
| FOG (Friend of GATA) family |
Alternative Names
FOG-1; FOG1ZNF408; FOGfriend of GATA-1; Friend of GATA 1; Friend of GATA protein 1; ZFN89A; Zinc finger protein 89A; Zinc finger protein multitype 1; zinc finger protein ZFPM1; zinc finger protein, multitype 1; ZNF89A
Molecular Weight
Mass (kDA):
105.984 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 8|8 E1 |
| Sequence: | 8; |
Tissue Specificity
Mainly expressed in hematopoietic tissues. Expressed in the spleen, a primary site of hematopoiesis in the adult mouse, as well as in the liver and testis, but not in the heart, brain, lung, kidney, or skeletal muscle. Among hematopoietic cell lines, it is strongly expressed in erythroid and megakaryocytic cell lines. Expressed at low level in several lymphoid and early myeloid cell lines. Not expressed in mast cell and macrophage lines. Expressed in the heart, where it colocalizes with GATA4, GATA5 and GATA6.
Diseases
- Anemia
- Leukemia
- Acute Erythroblastic Leukemia
- Myeloid Leukemia
- Gata1 Gene Mutation
- Beta Thalassemia
- Anemia, Sickle Cell
- Down Syndrome
- Malignant Neoplasms
- Hematological Disease
- Thalassemia
- Growth Arrest
Pathways
- Cell Development
- Cell Differentiation
- Cell Proliferation
- Megakaryocyte Development
- Chromatin Remodeling
- Cell Maturation
- Megakaryocyte Differentiation
- Cell Division
- Translation
- Histone Deacetylation
- Localization
- Heart Development
- Stem Cell Differentiation
PTMs
- Phosphorylation
- Deacetylation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Zfpm1
bosterbio.com/bosterbio-gene-info-cards/Zfpm1
References
PMID: 9230307 by Tsang A.P., et al. FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation.
PMID: 9553047 by Tsang A.P., et al. Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG.