mRNA decay activator protein ZFP36L2 (ZFP36L2)

Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by boosting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:25106868, PubMed:14981510). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to convey signaling events to the mRNA decay machinery (PubMed:25106868).

Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Promotes ARE- containing mRNA decay of this low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13- acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868).