Zbtb7b Antibodies

AND Zbtb7b ELISA kits, Zbtb7b Proteins

Many biological assays use antibodies to detect Zbtb7b, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Zbtb7b in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Zbtb7b antibodies...

We validate the specificity of these antibodies to Zbtb7b by testing them on tissues known to express Zbtb7b positively and negatively. Browse below to find the Zbtb7b antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Zbtb7b Infographic by Boster Bio

All Zbtb7b Products

Product

Figures

Specificity

Applications

Price

Anti-TH-POK ZBTB7B Monoclonal Antibody

Human

ELISA, IF, IHC, WB

$380
Cat # M06831
100ul

Anti-ZBTB7B Antibody (C-term)

Human

IF, WB

$298
Cat # A06831
80 µl

Zbtb7b Overview

Facts about Zinc finger and BTB domain-containing protein 7B.

Zinc finger and BTB domain-containing protein 7B (Zbtb7b)

Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells at a tissue-specific way (PubMed:15729333, PubMed:29420538).

Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T- cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively.

Gene Information

Mouse
Gene Name:	Zbtb7b
Uniprot:	Q64321
Entrez:	22724

Family

Belongs to:

No superfamily

Alternative Names

c-Krox; hcKroxc-Krox; Krueppel-related zinc finger protein cKrox; kruppel-related zinc finger protein hcKrox; T-helper-inducing POZ/Krueppel-like factor; ThPOK; Th-POK; ZBTB15; ZBTB15zinc finger protein 67 homolog (mouse); ZBTB7B; ZFP67; zfp-67; zinc finger and BTB domain containing 15; zinc finger and BTB domain containing 7B; Zinc finger and BTB domain-containing protein 15; zinc finger and BTB domain-containing protein 7B; Zinc finger protein 67 homolog; Zinc finger protein 857B; Zinc finger protein Th-POK; ZNF857B; ZNF857BDKFZp686G01254

Molecular Weight

Mass (kDA):
58.918 kDA

Genomic Context


Mouse

Location:	3 F1\|3 39.09 cM
Sequence:	3;

Tissue Specificity

Widely expressed, with a higher level in skin. Expressed in thymus. Restricted to CD4 cells (mature single positive CD4(+) and intermediate CD4(+)CD8(+) cells). Expressed in the luminal epithelial cells in the mammary glands where is up- regulated at late pregnancy and lactation (PubMed:29420538). Expression is enriched in brown fat (PubMed:28784777).

Diseases

Scleroderma
Lymphoma
Localized Scleroderma
Noonan Syndrome
Epithelioma
Peripheral T-cell Lymphoma
Thymoma
Pre-eclampsia
Tissue Adhesions
Fetal Growth Retardation
Diffuse Scleroderma
Sex Chromosome Aberrations
Immunologic Deficiency Syndromes

Neoplasms
Placenta Disorders
Dwarfism
Anaplasia
Cytogenetic Abnormality
Thymus Epithelial Neoplasm
Anoxia

Pathways

Cell Development
Cell Differentiation
Cell Adhesion
T Cell Differentiation
Cytokine Production
Translation
Dedifferentiation

Rna Interference
Transdifferentiation

PTMs

Acetylation
Deacetylation

Methylation
Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Zbtb7b

References

PMID: 7937772 by Galera P., et al. c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin.

PMID: 15729333 by He X., et al. The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment.