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14-3-3 protein theta Antibodies
AND YWHAQ ELISA kits, 14-3-3 protein theta Proteins
Many biological assays use antibodies to detect 14-3-3 protein theta, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with 14-3-3 protein theta in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop 14-3-3 protein theta antibodies...
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YWHAQ Infographic by Boster Bio
All YWHAQ Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # M03904
100 μl
Cat # M03904
100 μl
Human, Mouse, Rat
ELISA
$540
Cat # EKC2181
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2181
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
WB
$482
Cat # A03904S232
100ul
Cat # A03904S232
100ul
Human, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$405
Cat # A03904-2
100ul
Cat # A03904-2
100ul
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A03904S232-1
100ul
Cat # A03904S232-1
100ul
YWHAQ Overview
Facts about 14-3-3 protein theta.
14-3-3 protein theta (YWHAQ)
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.
Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
Gene Information
| Human | |
|---|---|
| Gene Name: | YWHAQ |
| Uniprot: | P27348 |
| Entrez: | 10971 |
Family
| Belongs to: |
|---|
| 14-3-3 family |
Alternative Names
14-3-3 protein tau; 14-3-3 protein T-cell; 14-3-3 protein theta; 1433; 14-3-3; 14-3-3,1C5; HS1; Protein HS1; protein tau; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, thetapolypeptide
Molecular Weight
Mass (kDA):
27.764 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p25.1 |
| Sequence: | 2; NC_000002.12 (9583967..9630997, complement) |
Tissue Specificity
Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.
Subcellular Localizations
Cytoplasm. In neurons, axonally transported to the nerve terminals.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma, Transitional Cell
- Malignant Neoplasm Of Prostate
- Sclerosis
- Primary Lateral Sclerosis
- Malignant Paraganglionic Neoplasm
- Amyotrophic Lateral Sclerosis
- Sarcoma
- Carcinoma
Interacting Proteins
- ARRB1
- ARRB2
- CBL
- CDC25A
- CDK14
- EGFR
- FSHR
- HDAC4
- KANK1
- LRRK2
Pathways
- Cell Cycle
- Brain Development
- Pathogenesis
- Localization
- Cell Cycle Arrest
- Kidney Development
PTMs
- Acetylation
- Isopeptide bond
Research Areas
- Alzheimers Research
- Cancer
- Cell Biology
- Cell Cycle and Replication
- Growth and Development
- Neuronal Cell Markers
- Neuroscience
- Phospho-Specific
- Protein Kinase
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/YWHAQ
bosterbio.com/bosterbio-gene-info-cards/YWHAQ
References
PMID: 2015305 by Nielsen P.J.; Primary structure of a human protein kinase regulator protein.
PMID: 8515476 by Leffers H., et al. Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway.