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14-3-3 protein epsilon Antibodies
AND YWHAE ELISA kits, 14-3-3 protein epsilon Proteins
Many biological assays use antibodies to detect 14-3-3 protein epsilon, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with 14-3-3 protein epsilon in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop 14-3-3 protein epsilon antibodies...
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YWHAE Infographic by Boster Bio
All YWHAE Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01687
100 μl
Cat # M01687
100 μl
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$405
Cat # A01687-3
100ul
Cat # A01687-3
100ul
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01687-4
100 μg/vial
Cat # A01687-4
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01687-2
100 μg/vial
Cat # M01687-2
100 μg/vial
Human, Mouse, Rat
ELISA, IF, IHC, ICC, WB
$370
Cat # A01687-5
100 μg/vial
Cat # A01687-5
100 μg/vial
YWHAE Overview
Facts about 14-3-3 protein epsilon.
14-3-3 protein epsilon (YWHAE)
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a lot of partners, usually by recognition of a phosphoserine or phosphothreonine motif.
Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326).
Gene Information
| Human | |
|---|---|
| Gene Name: | YWHAE |
| Uniprot: | P62258 |
| Entrez: | 7531 |
Family
| Belongs to: |
|---|
| 14-3-3 family |
Alternative Names
1433 epsilon; 14-3-3 epsilon; 14-3-3 protein epsilon; FLJ45465; FLJ53559,14-3-3E; KCIP-1; MDCR; MDS; mitochondrial import stimulation factor L subunit; protein kinase C inhibitor protein-1; tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilonpolypeptide; YWHAE
Molecular Weight
Mass (kDA):
29.174 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17p13.3 |
| Sequence: | 17; NC_000017.11 (1344275..1400262, complement) |
Subcellular Localizations
Nucleus. Cytoplasm. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Diseases
- Miller Dieker Syndrome
- Lissencephaly
- Malignant Neoplasms
- Neoplasms
- Developmental Delay (disorder)
- Classical Lissencephalies And Subcortical Band Heterotopias
- Autistic Disorder
- Growth Retardation
- Haploinsufficiency
- Lissencephaly I
- Schizophrenia
- Epilepsy
Interacting Proteins
- ACD
- APAF1
- ARAF
- CBY1
- CDK14
- DISC1
- DLD
- DLST
- FBXO4
- HDAC4
Pathways
- Cell Cycle
- Localization
- Brain Development
- Cell Proliferation
- Cell Adhesion
- Transport
- Cell Migration
- Neurogenesis
- Cytoskeleton Organization
- Cell Growth
- Pathogenesis
- Stem Cell Differentiation
- Aging
PTMs
- Phosphorylation
- Cleavage
- Glycosylation
Research Areas
- Cancer
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/YWHAE
bosterbio.com/bosterbio-gene-info-cards/YWHAE
References
PMID: 7644510 by Conklin D.S., et al. 14-3-3 proteins associate with cdc25 phosphatases.
PMID: 8858348 by Chong S.S., et al. 14-3-3 epsilon has no homology to LIS1 and lies telomeric to it on chromosome 17p13.3 outside the Miller-Dieker syndrome chromosome region.