This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
XPC Antibodies
AND XPC ELISA kits, XPC Proteins
Many biological assays use antibodies to detect XPC, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with XPC in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop XPC antibodies...
Previous: CBLIF
Next: XPNPEP1
XPC Infographic by Boster Bio
All XPC Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A00473-1
100 μg/vial
Cat # A00473-1
100 μg/vial
XPC Overview
Facts about DNA repair protein complementing XP-C cells.
DNA repair protein complementing XP-C cells (XPC)
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding variable component of this XPC complex. Has only a low DNA repair activity by itself that is stimulated by RAD23B and RAD23A.
Has a preference to bind DNA comprising a short single-stranded segment but to not damaged oligonucleotides. This feature is suggested to be connected to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded foundations by forming a transient nucleoprotein intermediate complicated which evolves into a steady recognition complex through an intrinsic single-stranded DNA- binding activity.
Gene Information
| Human | |
|---|---|
| Gene Name: | XPC |
| Uniprot: | Q01831 |
| Entrez: | 7508 |
Family
| Belongs to: |
|---|
| XPC family |
Alternative Names
complementation group C; p125; RAD4; Xeroderma pigmentosum group C-complementing protein; xeroderma pigmentosum, complementation group C; XP3; XPCCDNA repair protein complementing XP-C cells
Molecular Weight
Mass (kDA):
105.953 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p25.1 |
| Sequence: | 3; NC_000003.12 (14145145..14178672, complement) |
Subcellular Localizations
Nucleus. Chromosome. Cytoplasm. Omnipresent in the nucleus and consistently associates with and dissociates from DNA in the absence of DNA damage (PubMed:18682493). Continuously shuttles between the cytoplasm and the nucleus, which is impeded by the presence of NER lesions (PubMed:18682493).
Diseases
- Xeroderma Pigmentosum
- Malignant Neoplasms
- Xeroderma
- Neoplasms
- Xeroderma Pigmentosum, Complementation Group C
- Malignant Neoplasm Of Skin
- Carcinoma
- Skin Neoplasms
- Carcinogenesis
- Malignant Neoplasm Of Lung
- Lung Neoplasms
- Cockayne Syndrome
- Malignant Neoplasm Of Breast
Interacting Proteins
- CETN2
- DDB2
- ERCC3
- GTF2H1
- PSMC5
- RAD23B
Pathways
- Dna Repair
- Cell Cycle
- Hypersensitivity
- Mismatch Repair
- Cell Death
- Dna Replication
- Localization
- Aging
- Nucleotide-excision Repair
- Chromatin Remodeling
- Cell Cycle Arrest
- S Phase
- Pathogenesis
PTMs
- Phosphorylation
- Cleavage
- Methylation
- Ubiquitination
- Sumoylation
- Oxidation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/XPC
bosterbio.com/bosterbio-gene-info-cards/XPC
References
PMID: 8168482 by Masutani C., et al. Purification and cloning of a nucleotide excision repair complex involving the Xeroderma pigmentosum group C protein and a human homologue of yeast RAD23.
PMID: 12177305 by Khan S.G., et al. The human XPC DNA repair gene: arrangement, splice site information content and influence of a single nucleotide polymorphism in a splice acceptor site on alternative splicing and function.