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Wilms tumor protein Antibodies
AND WT1 ELISA kits, Wilms tumor protein Proteins
Many biological assays use antibodies to detect Wilms tumor protein, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Wilms tumor protein in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Wilms tumor protein antibodies...
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WT1 Infographic by Boster Bio
All WT1 Products
Product
Figures
Specificity
Applications
Price
Anti-Wilms Tumor Protein WT1 Rabbit Monoclonal Antibody
4 Citations 7 Q&As
Human, Mouse
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00199-1
100 μl
Cat # M00199-1
100 μl
Anti-Wilms tumor protein WT1 Antibody
2 Citations
Human, Mouse, Rat
ELISA, IF, IHC, WB
$405
Cat # A00199
100ul
Cat # A00199
100ul
WT1 Overview
Facts about Wilms tumor protein.
Wilms tumor protein (WT1)
Transcription factor that plays a significant role in mobile development and cell survival (PubMed:7862533). Regulates the expression of numerous target genes, including EPO.
Plays an important role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation.
Gene Information
| Human | |
|---|---|
| Gene Name: | WT1 |
| Uniprot: | P19544 |
| Entrez: | 7490 |
Family
| Belongs to: |
|---|
| EGR C2H2-type zinc-finger protein family |
Alternative Names
AWT1; GUD; NPHS4GUD; WAGR; Wilms tumor 1; Wilms tumor protein; WIT-2; WT1; WT33
Molecular Weight
Mass (kDA):
49.188 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p13 |
| Sequence: | 11; NC_000011.10 (32387775..32435539, complement) |
Tissue Specificity
Expressed in the kidney and a subset of hematopoietic cells.
Subcellular Localizations
Nucleus. Nucleus, nucleolus. Cytoplasm. Isoforms lacking the KTS motif have a diffuse nuclear location (PubMed:15520190). Shuttles between nucleus and cytoplasm.; [Isoform 1]: Nucleus speckle.; [Isoform 4]: Nucleus, nucleoplasm.
Diseases
- Neoplasms
- Nephroblastoma
- Leukemia
- Malignant Neoplasms
- Kidney Neoplasm
- Myeloid Leukemia
- Leukemia, Myelocytic, Acute
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Denys-drash Syndrome
- Cell Transformation, Neoplastic
- Kidney Diseases
- Neoplasm, Residual
Interacting Proteins
- KRT40
- KRTAP10-8
Pathways
- Kidney Development
- Pathogenesis
- Methylation
- Cell Proliferation
- Sex Determination
- Localization
- Cell Growth
- Cell Cycle
- Cell Differentiation
- Dna Methylation
- Cell Death
- Reverse Transcription
- Angiogenesis
PTMs
- Methylation
- Phosphorylation
- Cleavage
- Demethylation
- Sumoylation
- Reduction
- Acetylation
Research Areas
- Angiogenesis
- Cancer
- Cell Cycle and Replication
- Cellular Markers
- Chromatin Research
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WT1
bosterbio.com/bosterbio-gene-info-cards/WT1
References
PMID: 2154702 by Gessler M., et al. Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping.
PMID: 1658787 by Haber D.A., et al. Alternative splicing and genomic structure of the Wilms tumor gene WT1.
4 Publications of Boster Wilms tumor protein Antibodies & ELISA Kits
- PubMed ID: 10.1016/j.molmet.2020.101089, P2Y2R contributes to the development of diabetic nephropathy by inhibiting autop...
- PubMed ID: 32987187, Dusabimana T,Kim SR,Park EJ,Je J,Jeong K,Yun SP,Kim HJ,Kim H,Park SW.P2Y2R contr...
- PubMed ID: 33562139, Dusabimana T,Park EJ,Je J,Jeong K,Yun SP,Kim HJ,Kim H,Park SW.Geniposide Improve...
- PubMed ID: 23724119, Sun D, Bu L, Liu C, Yin Z, Zhou X, Li X, Xiao A. Plos One. 2013 May 28;8(5):E650...
*More publications can be found for each product on its corresponding product page