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Facts about Protein Wnt-7a.
Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes (By similarity).
Human | |
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Gene Name: | WNT7A |
Uniprot: | O00755 |
Entrez: | 7476 |
Belongs to: |
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Wnt family |
protein Wnt-7a; proto-oncogene Wnt7a protein; wingless-type MMTV integration site family, member 7A; Wnt7a; Wnt-7a
Mass (kDA):
39.005 kDA
Human | |
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Location: | 3p25.1 |
Sequence: | 3; NC_000003.12 (13816258..13880071, complement) |
Expression is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain.
Secreted, extracellular space, extracellular matrix. Secreted.
PMID: 9161407 by Bui T.D., et al. Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25.
PMID: 8893824 by Ikegawa S., et al. Isolation, characterization and chromosomal assignment of the human WNT7A gene.
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