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Protein Wnt-5a Antibodies
AND WNT5A ELISA kits, Protein Wnt-5a Proteins
Many biological assays use antibodies to detect Protein Wnt-5a, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein Wnt-5a in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein Wnt-5a antibodies...
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WNT5A Infographic by Boster Bio
All WNT5A Products
Product
Figures
Specificity
Applications
Price
Anti-Wnt5a Antibody Picoband®
2 Citations 5 Q&As
Human, Mouse, Rat
IHC, WB
$370
Cat # PB9063
100 μg/vial
Cat # PB9063
100 μg/vial
Human
Flow Cytometry, IF, ICC, WB
$370
Cat # M00549
100 μl
Cat # M00549
100 μl
WNT5A Overview
Facts about Protein Wnt-5a.
Protein Wnt-5a (WNT5A)
Can trigger or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling.
In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation via a GSK3-independent pathway that involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to happen and inhibits tumor formation.
Gene Information
| Human | |
|---|---|
| Gene Name: | WNT5A |
| Uniprot: | P41221 |
| Entrez: | 7474 |
Family
| Belongs to: |
|---|
| Wnt family |
Alternative Names
hWNT5A; protein Wnt-5a; wingless-type MMTV integration site family, member 5A; WNT-5A protein; Wnt5a; Wnt-5a
Molecular Weight
Mass (kDA):
42.339 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p14.3 |
| Sequence: | 3; NC_000003.12 (55465715..55505261, complement) |
Tissue Specificity
Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level) (PubMed:15735754). Detected in neonate heart and lung (PubMed:8288227).
Subcellular Localizations
Secreted, extracellular space, extracellular matrix. Secreted.
Diseases
- Malignant Neoplasms
- Neoplasms
- Neoplasm Metastasis
- Carcinoma
- Cell Transformation, Neoplastic
- Malignant Paraganglionic Neoplasm
- Tissue Adhesions
- Cell Invasion
- Melanoma
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Neoplasm Invasiveness
- Carcinogenesis
Interacting Proteins
- WIF1
Pathways
- Cell Proliferation
- Cell Migration
- Localization
- Cell Growth
- Secretion
- Cell Adhesion
- Pathogenesis
- Gastrulation
- Convergent Extension
- Cell Differentiation
- Methylation
- Cell Cycle
- Cell Motility
PTMs
- Phosphorylation
- Methylation
- Cleavage
- Demethylation
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WNT5A
bosterbio.com/bosterbio-gene-info-cards/WNT5A
References
PMID: 8288227 by Clark C.C., et al. Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21.
PMID: 14610063 by De Cat B., et al. Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements.
2 Publications of Boster Protein Wnt-5a Antibodies & ELISA Kits
- PubMed ID: 10.1007/s11255-016-1291-2, Aberrant activation of Wnt pathways in arteries associates with vascular calcifi...
- PubMed ID: , Osteogenesis potential of different titania nanotubes in oxidative stress microe...
*More publications can be found for each product on its corresponding product page