Protein Wnt-3a Antibodies

Protein Wnt-3a (Wnt3a)

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that leads to activation of transcription factors of the TCF/LEF household (PubMed:26902720).

Required for normal embryonic mesoderm development and formation of caudal somites (PubMed:8299937). Required for normal morphogenesis of the developing neural tube (PubMed:8299937).

Gene Information

Mouse
Gene Name:	Wnt3a
Uniprot:	P27467
Entrez:	22416

Family

Belongs to:
Wnt family

Alternative Names

MGC119418; MGC119419; MGC119420; protein Wnt-3a; wingless-type MMTV integration site family, member 3A; Wnt3a; Wnt-3a

Molecular Weight

Mass (kDA):
39.258 kDA

Genomic Context

Mouse
Location:	11 B1.3|11 37.17 cM
Sequence:	11;

Tissue Specificity

Dorsal portion of the neural tube (developing roof plate), and mesenchyme tissue surrounding the umbilical veins.

Diseases

• Malignant Neoplasms
• Neoplasms
• Cell Transformation, Neoplastic
• Carcinoma
• Tissue Adhesions
• Nervousness
• Leukemia
• Carcinogenesis
• Mammary Neoplasms
• Malignant Neoplasm Of Breast
• Crest Syndrome
• Malignant Neoplasm Of Stomach
• Malignant Neoplasm Of Prostate

• Colorectal Cancer
• Prostatic Neoplasms
• Congenital Abnormality
• Polyposis
• Malignant Paraganglionic Neoplasm
• Cell Invasion
• Embryonal Carcinoma

Pathways

• Cell Proliferation
• Regeneration
• Osteoblast Differentiation
• Cell Growth
• Localization
• Pathogenesis
• Cell Cycle
• Secretion
• Cell Differentiation
• Gastrulation
• Cell Migration
• Segmentation
• Neurogenesis

• Rna Interference
• Somitogenesis
• Cell Adhesion
• Oncogenesis
• Cell Development
• Angiogenesis
• Bone Resorption

PTMs

• Phosphorylation
• Methylation
• Glycosylation
• Palmitoylation
• Ubiquitination
• Cleavage

• Acetylation
• Dephosphorylation
• Demethylation
• Acylation
• Biotinylation
• Reduction

• Prenylation

Research Areas

• Signal Transduction
• Stem Cell Signaling Pathway
• Wnt Signaling Pathway

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Wnt3a

Boster Bio - The Best Uses Of The WNT3A Marker

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OA synovium

Despite the fact that clinical trials have not been able to find a cure for OA, there are some reasons to believe that there may be better results. Disease heterogeneity is often suggested as the reason for such poor outcomes. Dell'Isola and his colleagues recently identified six major OA phenotypes. Only 12% of these phenotypes were non-inflammatory. Other phenotypes included mechanical overload, chronic pain, and minimal disease.

Wnt signaling in OA is linked to cartilage degrading. This was first demonstrated by the DMM model. It is a traumatic OA simulation that involves the transection of the medial mescotibial ligament. The OA model can be improved by ablation Wnt signaling. This suggests that WNT3A could play a role during the development of OA.

WNT-3A sends signals to many cell types by activating a canonical Wnt pathway. It also stimulates AXIN2 & PCNA by a canonical pathway. It also down-regulates COL2A1 & SOX9. These results have implications for OA treatments. This review summarizes the current understanding of the role of WNT3A signaling in OA and discusses potential applications of molecules targeting the Wnt pathway.

There are some promising applications of OA. However further studies are needed to understand if synovial hyperexpression of WNT signaling pathway may affect the development. However, it should be noted that the current research is limited to a small subset of patients with OA. It is essential to have a better understanding about the role of synovial wnt signaling in OA.

The study showed that different subsets OA Synovial Macrophages display distinct phenotypes. Differentiation of Wnt3a was shown to influence chondrocyte proliferation, while Dkk1 effected the opposite. These results suggest that increased Wnt signaling could potentially cause cartilage destruction. Therefore, determining how WNT3A signaling affects OA may be critical to the development of novel therapeutics.

WNT3A signaling has been linked to the release of key OA mediators in the joint space. The study also showed HLA-DRA-positive synovium cells expressed 25 times more cytokines compared to chondrocyte-rich regions. These proteins could also be involved in cartilage breakdown and inflammation. This suggests that they might be useful in OA therapy to target specific tissue parts.

Cancer

WNT3A is a key tumor suppressor gene. Cancer cells possess unique properties including anchorage-independent growth. They can become invasive through matrigel material if they are overexpressed for this gene. The WNT3A gene has been identified as a key target for researchers in tumor cells. This article will describe the most popular uses of WNT3A. Read on to learn more.

While Wnt3a expression has been shown to be associated with invasive properties it is also linked to metastatic abilities. Researchers have used the WNT3A marker in human colon cancer and linked it to clinical characteristics like stage and recurrence. Furthermore, it is associated with the expression of EMT-associated proteins like b-catenin and E-cadherin.

Wnt3a interacts with signaling molecules, including PI3K/AKT. It also promotes invasion of humantrophoblasts by influencing MMP-2 secretion. Researchers are currently studying the WNT3A's interactions and other EMT-associated signaling pathway. The WNT3A gene plays a pivotal role in tumor-reactive protein production and cell survival.

Wnt signaling disorder is linked with aging-related diseases and aging. It also increases cartilage degeneration in OA sufferers. In the rat model, disordered WNT signaling impairs the differentiation of stem cells in the synovium. It does have mild protective effects on cartilage integrity.

WNT3A genes are expressed in many cell types, including lung, colon, liver and colon. This gene can be found in the stroma, which is a part of all mammary glands. Wnt3a overexpression in cancer cells results in increased expression of the mesenchymal markers c-myc and CyclinD1. WNT3A regulates cell growth in cancer cells.

Bone marrow

WNT3A is an osteoblast differentiation marker. It has also been shown to regulate stromal cells and play an important role in the differentiation process. These effects were specific to the stromal lines, as measured by STRO-1 transcription. This is a first-of-its-kind report that describes bone marrow uses for the WNT3A gene marker.

This gene is involved in many processes, including cell growth and cell death. It is also involved in skeletal and muscular development, cell-to-cell signaling, and osteogenesis. It was first discovered in mice, and it is used to diagnose osteoporosis in people. It has many uses in bone-marrow. The WNT3A bone loss marker has been used in humans.

Wnt3A stimulation is known to increase the number and quality of BMMNCs with stromal cells in humans. Wnt signals alone do not promote bone growth, but prolonged exposure to Wnt can lead to osteogenesis. Therapeutic approaches targeting Wnt signalsing must take into account the complex requirements of Wnt Signaling in bone marrow. Despite this, WNT3A stimulation enhances the proliferation of the BMMNC population and is a useful tool for studying bone development.

WNT3A is associated with bone marrow liposomes. Wnt3A was associated most quickly with the CD14+ population of monocytes. It was also highly associated with macrophages. These cells are the principal cell type involved for liposome clearance. In addition, liposome-encapsulated clodronate selectively depletes macrophages, resulting in an increase in STRO-1+/GPA cells.

This study shows that Wnt3A significantly increases CD45, STRO-1 and GPA. These cells are known to be mesenchymal stem cells, and Wnt3A is believed to have an effect on them. In addition, Wnt3A also influences cell-to-cell signaling and interaction. Wnt3A significantly increased the expression of four CCN genes. These genes are essential for the differentiation bone marrow stem cell cells.

The WNT3A marker can also be used to detect chemoresistries that target other tissues. It may also be useful for monitoring the progression and spread of cancer. The WNT3A markers have many clinical implications, not only in bone marrow. It is important to understand how this discovery was made. There are many ways to identify cancer cells. WNT3A is the most well-studied cell surface protein.

Stem cells

The neural crest is a model system for stem-cell biology. The neural crest cells progenitor of many types neuronal and nonneural cells and delaminate in the developing dorsal nervous tube. Some cases are multipotent with characteristics typical of stem cells such as the ability to self-renew and self-renew. This marker could be used to identify neural stem cells, as was demonstrated in a recent study.

The Wnt3A gene binds to E-boxes in the promoter of E-cadherin. The cytoskeletal architecture of mesenchymal cellular cells is altered by increasing Wnt3a. Tumor cells with a high Wnt3a level are more invasive. These findings suggest that this gene may be overexpressed in order to promote mesenchymal division in stem cells.

NCSCs are multipotent, co-existing with cells with restricted developmental capabilities. The Wnt3A genes is responsible for maintaining the balance between these types of cells. It has been shown that the Wnt3A genes promote NCSC growth, while Sox10 inhibits differentiation. WNT3A can be used in stem cell research because it is a very specific marker.

The WNT3A marker is associated with liposomes in human bone marrow mononuclear cells. The CD14+ population saw the greatest uptake. This population includes macrophages at various stages of cell commitment as well as STRO-1+/GPA and macrophages. Macrophages are the principal cell type responsible for liposome clearance, and liposome-encapsulated clodronate can selectively deplete macrophages from STRO-1+/GPA cells.

WNT3A+ MSCs were used in differentiation of iPSCs into a variety different cell types. They were grown in expansion medium for one to three days, three days, and six day. Each passage was repeated three more times until they reached 2300 cells/cm2, at which point they remained for the rest of the time. The number recipient cells was determined using the count of how many cells/cm2 each condition contained.

In mice, the WNT3A gene is overexpressed. This causes tumors in the lymph nodes and lungs. It also inhibits the growth of adult stem cells. However, there are many other benefits. WNT3A can be found in many types of cancer and can provide valuable information for both scientists and patients. WNT3A can be found in tumor cells and can provide information that will help to identify the disease.