Proto-oncogene Wnt-3 Antibodies

Proto-oncogene Wnt-3 (WNT3)

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that leads to activation of transcription factors of the TCF/LEF household (PubMed:26902720).

Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity).

Gene Information

Human
Gene Name:	WNT3
Uniprot:	P56703
Entrez:	7473

Family

Belongs to:
Wnt family

Alternative Names

INT4Proto-oncogene Int-4 homolog; MGC131950; MGC138321; MGC138323; proto-oncogene Wnt-3; wingless-type MMTV integration site family, member 3; WNT-3 proto-oncogene protein

Molecular Weight

Mass (kDA):
39.645 kDA

Genomic Context

Human
Location:	17q21.31-q21.32
Sequence:	17; NC_000017.11 (46762506..46818692, complement)

Subcellular Localizations

Secreted, extracellular space, extracellular matrix. Secreted.

Diseases

• Malignant Neoplasms
• Neoplasms
• Cell Transformation, Neoplastic
• Carcinoma
• Mammary Neoplasms
• Nervousness
• Carcinogenesis
• Tissue Adhesions
• Congenital Abnormality
• Malignant Neoplasm Of Breast
• Cleft Palate
• Cleft Lip
• Crest Syndrome

• Malignant Paraganglionic Neoplasm
• Malignant Neoplasm Of Stomach
• Embryonal Carcinoma
• Leukemia
• Hyperplasia
• Liver Carcinoma
• Polyposis

Interacting Proteins

• FZD7

Pathways

• Cell Proliferation
• Regeneration
• Cell Growth
• Localization
• Osteoblast Differentiation
• Neurogenesis
• Gastrulation
• Cell Differentiation
• Pathogenesis
• Secretion
• Rna Interference
• Somitogenesis
• Cell Migration

• Cell Cycle
• Segmentation
• Glycosylation
• Cell Adhesion
• Angiogenesis
• Oncogenesis
• Axon Guidance

PTMs

• Phosphorylation
• Glycosylation
• Cleavage
• Ubiquitination
• Palmitoylation
• Dephosphorylation

• Acetylation
• Demethylation
• Acylation
• Gpi Anchoring
• Reduction
• Methylation

• Myristoylation

Research Areas

• Stem Cell Signaling Pathway
• Wnt Signaling Pathway

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WNT3

Best Uses Of The WNT3 Marker

The Boster Bio website provides a number of educational resources. The information can be downloaded as PDFs. If you use any of our resources, please link back to the source and cite the original source. These resources can also be shared with educators. We hope that you find them useful. These resources can be shared with students, faculty, or industry professionals. We also encourage you to cite the references and resources on our website.

Resources

WNT3 is a marker for DE differentiation. WNT3 expression in hESCs predicts the DE-differentiated hESCs' differentiation ability under different conditions. However, there is some uncertainty about the relationship between WNT3 expression and differentiation efficiency. This study sought to determine whether the WNT3 gene can be used as a marker of DE differentiation ability. In addition, the WNT3 gene is known to be a positive regulator of the differentiation potential of hESCs.

WNT3 plays a crucial role in the formation of PS/DE. Inhibition of this gene inhibits mesendoderm differentiation. The qRT-PCR analysis confirmed this result. While the differentiation efficiency of different hESC lines varied, MEL-1 showed the highest WNT3 level and the greatest DE differentiation potential. WNT3 has been shown to be highly expressed both in DE and PS.

WNT3 levels in hESCs are an indicator of their ability to differentiate into different lineages including neuroectoderm and mesoderm. While WNT3 does not affect pluripotency, its expression levels in hESCs have been found to increase the activity of key endoderm lineage factors, making them poised for DE differentiation. However, further research is needed to determine the relationship between WNT3 gene expression and DE differentiation potential.

PDFs

Boster Bio offers a variety of ELISA kits that can detect inflammatory cytokines and hormones, small molecules, oxidative damage, and DNA damages. These kits have enough reagents that they can perform 96 tests. They can be used with a variety sample types including plasma, human serum, and mouse blood. They can detect IL-6, IL-8, IL-10, EGF, as well other cytokines.

Resources for researchers

WNT3a, a key tumor suppressor protein, is important. It is associated to colon cancer histological differentiation (metastatic potential), survival time, as well as colon cancer survival time. WNT3a also has several characteristics of EMT, such as decreased expression of E-cadherin, increased expression vimentin, and b-catenin. In addition, it may alter cell morphology and regulate EMT-associated protein expression.

Wnt3a is a potent activator of Wnt/b-catenin signaling. It regulates the progression in various cancers. However, few studies have been conducted to determine the role of this gene for cancer. These resources can be used by researchers to study the WNT3 gene marker:

The Wnt signaling pathway has been implicated for many human diseases. It is central to embryogenesis. Abnormal signaling has been linked to many types of cancer and degenerative disease. Wnt Ligands are cysteinerich glycoproteins that activate multiple intracellular pathway signaling pathways. They play critical roles in cell growth, tissue homeostasis, stem cell maintenance, and cell fate decision.