Protein Wnt-2 Antibodies

Protein Wnt-2 (WNT2)

Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that leads to activation of transcription factors of the TCF/LEF household (PubMed:20018874).

Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung growth.

Gene Information

Human
Gene Name:	WNT2
Uniprot:	P09544
Entrez:	7472

Family

Belongs to:
Wnt family

Alternative Names

INT1L1; INT1L1secreted growth factor; Int-1-like protein 1; Int-1-related protein; IRP; IRPprotein Wnt-2; wingless-type MMTV integration site family member 2; Wnt2; Wnt-2

Molecular Weight

Mass (kDA):
40.418 kDA

Genomic Context

Human
Location:	7q31.2
Sequence:	7; NC_000007.14 (117275451..117323058, complement)

Tissue Specificity

Expressed in brain in the thalamus, in fetal and adult lung and in placenta.

Subcellular Localizations

Secreted, extracellular space, extracellular matrix. Secreted.

Diseases

• Malignant Neoplasms
• Neoplasms
• Carcinoma
• Malignant Paraganglionic Neoplasm
• Malignant Neoplasm Of Stomach
• Cell Transformation, Neoplastic
• Autistic Disorder
• Carcinogenesis
• Stomach Neoplasms
• Neoplasm Metastasis
• Mammary Neoplasms
• Malignant Neoplasm Of Breast

• Adenocarcinoma
• Colorectal Cancer
• Colonic Neoplasms
• Fibrosis
• Metastatic Malignant Neoplasm To The Lymph Node
• Neoplasm Invasiveness
• Esophageal Neoplasms

Pathways

• Cell Proliferation
• Localization
• Pathogenesis
• Lung Development
• Glycosylation
• Cell Differentiation
• Cell Growth
• Regeneration
• Angiogenesis
• Methylation
• Cell Migration
• Lung Growth
• Cellular Senescence

• Neurogenesis
• Gastrulation
• Senescence
• Cell Cycle
• Lung Morphogenesis
• Cell Death
• Organ Development

PTMs

• Phosphorylation
• Glycosylation

• Methylation
• Ubiquitination

• Demethylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WNT2

Best Uses Of The WNT2 Marker

WNT2 (a ubiquitous protein found in the human body) is frequently used for cancer research. This article will discuss the benefits and uses of WNT2 as well as other immunogenic proteins such Picokine or Picoband. This article also discusses IHC-optimized, polyclonal antibodies as well as Custom services. Listed below are a few of the highlights of these products.

Picokine

WNT2 belongs to the Wnt transmembrane family, which is involved in several developmental processes. It was found in the placenta, early heart field, and placenta in mice eight days after conception. It was also found in placenta and umbilicus at 14.5 dpc. Mice without Wnt2 showed runting, while mice with Wnt2 displayed abnormal placental structures.

Picoband

The WNT2 family includes secreted signaling protein WNT2. It is involved on many developmental processes, including embryonic development and oncogenesis. It has been implicated in cell fate regulation, patterning, and embryonic growth. The WNT gene family encodes many different protein isoforms. In addition to WNT2, the WNT2 gene has been involved in alternative splicing.

IHC-optimized monoclonal antibodies

Immunohistochemistry can be used to diagnose, investigate, and treat a variety of diseases. It was used for the first time in 1942. The technique has seen substantial improvements over time and is still widely used today. This review will cover the essential information and principles of immunohistochemistry. It will also discuss the many variables that can impact the results and provide links to peer review publications. It will cover important aspects in immunohistochemistry and how it can be used in various clinical settings.

IHC allows the detection and quantification of specific proteins. Although most antibodies can be used with relative confidence for IHC, there are exceptions. It is important that you use the correct controls and a reliable fixation time to determine which antibodies are best for specific applications. This method is reliable for many applications but it is important to have a good understanding of the biology of the proteins in order to get the best results.

Polyclonal antibodies are made from several B-cell clones. Each clone can detect different epitopes on a particular protein. In many IHC/ICC applications, polyclonal antibody are very useful. Polyclonal antibodies are preferred for IHC/ICC experiments because they can recognize multiple epitopes. Polyclonal antibodies have many benefits but can alter the protein conformation.

Background staining can sometimes be reduced with IHC-optimized Polyclonals Antibodies using the WNT2 Marker. Antibodies with antigen-specific affinity will interact more closely with the antigen, which can reduce background staining. It also produces more reproducible results. They should not be used in IHC because they can cause a higher non-specific signal. There is a wide range of dilution range for polyclonal antibodies, and Novus Biologicals recommends a dilution range based on the application.

BeNeLux deliveries

Recent research suggests that regulators of WNT signaling could be effective drugs to treat osteoarthritis. However, such an approach requires a better understanding of how Wnt signals are regulated and how they may be targeted. A recent study published in Biomedical research found that Wnt signaling regulators might be useful drugs to treat osteoarthritis. These results have a positive effect on osteoarthritis research.