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Wee1-like protein kinase Antibodies
AND WEE1 ELISA kits, Wee1-like protein kinase Proteins
Many biological assays use antibodies to detect Wee1-like protein kinase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Wee1-like protein kinase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Wee1-like protein kinase antibodies...
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WEE1 Infographic by Boster Bio
All WEE1 Products
Product
Figures
Specificity
Applications
Price
Anti-WEE1 Antibody Picoband®
1 Q&As
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01319-1
100 μg/vial
Cat # A01319-1
100 μg/vial
Human, Mouse, Rat
ELISA
$480
Cat # EKC1599
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1599
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2330
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2330
1 kit, containing two 96-well plates and all necessary reagents
WEE1 Overview
Facts about Wee1-like protein kinase.
Wee1-like protein kinase (WEE1)
Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase.
Phosphorylation of cyclin B1-CDK1 happens only on'Tyr-15' and phosphorylation of monomeric CDK1 doesn't occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated.
Gene Information
| Human | |
|---|---|
| Gene Name: | WEE1 |
| Uniprot: | P30291 |
| Entrez: | 7465 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
DKFZp686I18166; EC 2.7.10.2; FLJ16446; WEE1 homolog (S. pombe); wee1+ (S. pombe) homolog; WEE1+ homolog; Wee1A kinase; WEE1A; WEE1hu; wee1-like protein kinase
Molecular Weight
Mass (kDA):
71.597 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p15.4 |
| Sequence: | 11; NC_000011.10 (9573670..9589985) |
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Encephalomyelitis, Western Equine
- Leukemia
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Growth Arrest
- Endoreduplication
- Colonic Neoplasms
- Malignant Tumor Of Colon
Interacting Proteins
- BTRC
- FBXW11
- YWHAZ
Pathways
- Cell Cycle
- Mitosis
- Cell Division
- Cell Cycle Arrest
- Dna Replication
- S Phase
- Interphase
- Cell Death
- M Phase
- Cell Proliferation
- Localization
- Cell Growth
- Dna Damage Checkpoint
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
Research Areas
- Cell Cycle and Replication
- Checkpoint signaling
- Core ESC-Like Genes
- DNA Double Strand Break Repair
- DNA Repair
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WEE1
bosterbio.com/bosterbio-gene-info-cards/WEE1
References
PMID: 7743995 by Watanabe N., et al. Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle.
PMID: 11528126 by Cichutek A., et al. Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1).