VEGFB Antibodies

Vascular endothelial growth factor B (VEGFB)

Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.

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Gene Information

Human
Gene Name:	VEGFB
Uniprot:	P49765
Entrez:	7423

Family

Belongs to:
PDGF/VEGF growth factor family

Alternative Names

vascular endothelial growth factor B; VEGFB; VEGF-B; VEGF-related factor; VRFVEGFL

Molecular Weight

Mass (kDA):
21.602 kDA

Genomic Context

Human
Location:	11q13.1
Sequence:	11; NC_000011.10 (64234584..64239264)

Tissue Specificity

Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.

Subcellular Localizations

Secreted. Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.

Diseases

• Tumor Angiogenesis
• Neoplasms
• Pathologic Neovascularization
• Malignant Neoplasms
• Carcinoma
• Hypoxia
• Neoplasm Metastasis
• Ischemia
• Cell Invasion
• Hypertrophy
• Neoplasm Invasiveness
• Anoxia

• Hypertensive Disease
• Liver Neoplasms
• Malignant Paraganglionic Neoplasm
• Inflammation
• Edema
• Myocardial Ischemia
• Infarction

Pathways

• Angiogenesis
• Lymphangiogenesis
• Transport
• Cell Proliferation
• Localization
• Cell Growth
• Cell Migration
• Reverse Transcription
• Chemotaxis
• Epithelial To Mesenchymal Transition
• Regeneration
• Mast Cell Chemotaxis
• Cell Adhesion

• Hyperphosphorylation
• Monocyte Chemotaxis
• Aging
• Proteolysis
• Dna Demethylation
• Complement Activation
• Neurogenesis

PTMs

• Phosphorylation

• Methylation

• Demethylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/VEGFB

Boster Bio - Best Uses Of The VEGFB Marker

Developed as an anti-coagulant protein, Boster Bio acts as an indirect inhibitor of the thromboplastin-specific complex, a key component of the blood coagulation cascade. To ensure optimal performance, the protein comes with troubleshooting and optimization tips. These guides can help you identify possible errors and offer solutions if your results do not meet your expectations.

Boster Bio NGF (Polypeptide) regulates neuronal development

Nerve growth factor, also known as NGF, is a polypeptide hormone that controls the growth, differentiation, and survival of neurons. It is important in drug development and medical diagnosis as well as in cancer research. This Boster Biologics NGF review will explain the benefits of this hormone, as well its role during neuronal development. You will learn how it affects the body and how it can improve treatment outcomes for a number of conditions.

Nerve growth factor (NGF), a polypeptide hormone, regulates the development and function of sympathetic and sensory neurons. It acts as an extracellular receptor ligand and promotes neuronal proliferation and differentiation. The human chromosome 1p22 contains the beta-subunit of NGF, while the mouse has chromosome 3. Pain perception in mice is affected by mutations in the nerve-growth factor beta gene. Boster Bio NGF regulates neuronal growth by targeting this hormone on receptor complexes and turning on genes involved with differentiation.

Boster Biologicals develops research antibodies and ELISA kit kits for the detection biomarkers in neurosciences, cancer, and developmental biology. These kits can detect biomarkers up to a picogram. tebu-bio offers the immunological products of the company. You can find Boster Bio NGF at tebu-bio.

The Boster Bio-NGF assay uses the same medium that was used to study the mice. It contains Glutathione, a reducing agent, and large amounts of vitamins. It can support the development of many types of mammalian cells and requires only five to 10 percent CO2.

Human NGF is an important factor in memory and learning. It is also responsible to the growth of neurons and protects cartilage. NGF, which is a dimer for 2.5S NGF, is produced in the human body. The human NGF protein consists of two polypeptide chain of 120 amino acids linked together. Boster Bio NGF is a highly useful hormone and regulates neuronal development.

Boster Bio ELISA Kit is validated for biologically relevant matrices

ELISA kit kits include all necessary reagents for conducting an ELISA analysis. Specific antibodies are linked with enzymes to enable rapid and accurate detection. There are many different types of ELISA. Each format uses a different method of antibody-antigen interaction. The Boster Bio ELISA kit, for instance, contains high affinity antibodies that detect native form proteins. Boster's QC department validates ELISA kits against immunogenic proteins and superfamilies.

The ELISA test is able to determine the cell's response against a variety toxic substances including hormones and pesticides. A sensitive ELISA can also measure hormone levels and detect key components (b-catenin/Dkk-1) of Wnt signalsing. ELISA is a sensitive test that can detect a wide variety of biologically relevant matrices, which is superior to other methods.

Boster Bio is a manufacturer high-sensitivity antibodies and has a broad product line to support research in many fields. In addition to ELISA kits, the company also produces antibodies and reagents for other diagnostic and research applications. Boster Bio's ELISA kit has been approved for use in a variety biologically relevant matrices including plasma, cell culture medium and RNA/DNA/RNA.

Boster ELISA Kits should be reproducible despite the importance of accuracy. Boster Bio spends considerable effort documenting lot-to-lot variability, and their assays should be reproducible. The coefficients of variation are less than 10%, meaning that the results will be reliable. The assays are highly reproducible. They can also measure inter and intra-assay precision.

Therefore, the BosterBio ELISA kit is recommended to be used in research studies of neuropeptides. The company also stocks anti-Syncytin-2 ERVFRD-1 antibody, which is available in Liquid form. It reacts to Humans. Its validity is based on its ability to detect the peptides in the samples used for the test.

Boster Bio's Annexin A5 antibodies are specific for VEGF Receptors

This peptide binds VEGF receptacles and neutralizes them. It binds VEGFR1 & VEGFR2 by using a mutated human VEGF 121. CIGB-247's ability to block proangiogenic activities isn't restricted to VEGF-receptors.

VEGF-1A stimulates PDGFR tyrosine kinases. But VEGF-1A, its two subtypes, and VEGF-2 activate their respective receptors on a different basis. The PDGFR family members activate the PI3K-Akt pathway, but VEGFR-2 is preferentially activated through the PLCg-PKC-MAPK pathway. The VEGF/VEGFR system is a promising target both for pro- and anti-angiogenic therapies.

VEGFA protein consists primarily a combination of peptides containing 121 and 165 amino acids, as well as 189. The 165-amino amino acid basic stretch has weak affinities for acidic materials but a high affinity of heparin/heparan. VEGFA-A 189 has strong affinity to the extracellular matrix.

CIGB-247 induces a polyclonal response, which includes VEGF-D blocking antibodies. Two ELISA formats are available to test this. If both formats were positive, the patient is seroconverted. CIGB-247 is also known to induce IgG antibodies that have high affinity to VEGF. It was then detected with a biotinylated anti-human monoclonal mouse monoclonal antibody.

CIGB-247 inducing an antibody response specific for VEGF. This is highly immunegenic and safe. It blocks the interaction between VEGF and VEGFR2 and -a, which means that it inhibits cell growth. The antibody can also block the interaction between the two VEGF receptors and bevacizumazumazumazumazuma.

This peptide has a high selectivity for the VEGF-receptors and can block their activity. It is available as a peptide that blocks the IGF1R or the VEGF receptor in two formats. It can also block the VEGF receptors found in human blood cells. This product also has many other benefits. Annexin A5 antibody is an option if you are looking for a peptide that targets a specific receptor.

Decorin is a leucine-rich protein that primarily expresses in mesenchymal cells. This peptide reduces the pro-fibrotic effects TGF-b has on failing hearts. It also promotes angiogenesis. This is an exciting immunotherapy. Boster Bio's Annexin A5 antibodies can be purchased now for treatment of a variety cardiovascular diseases.

Boster Bio's CD146 Biomarker encourages angiogenesis

Although it is an important biomarker for angiogenesis (biomarker), little is known about its molecular mechanisms. While CD146 and Wnt5a are known binding partners, other mechanisms are ambiguous. While CD146 and Wnt5a are known to play similar roles as ligands, their relative importance is still debated. However, there is a lot of evidence supporting the hypothesis that CD146 promotes angiogenic activity by regulating the activity vascular endothelial cell.

CD146 is an immunoglobulin-superfamily cell adhesion molecule that plays a key role in physiological as well as pathological angiogenesis. Several cancers, including melanoma, have been shown to express CD146. This protein has important roles in tumor invasion and metastasis. CD146-CD146 function is dependent on netrin. The role of CD146 as a biomarker has been studied in the vascular systems.

In vitreous samples from diabetic patients, CD31-CD146 expression levels were also examined. PDR was also linked to the presence and levels of both proteins found in vitreous tissues. PDR vitreous tissue had higher levels of sCD146 than the non-diabetic controls. The same data was obtained when comparing the two groups, using a Kruskal-Wallis test.

CD146 expression has also been found in human peripheral circulation. Although its expression was not initially significant, subsequent studies showed that it was increased in the presence of mitogens, and activated by IL-4. It is currently being investigated for possible therapeutic targets in cancer patients. Boster Bio's CD146 biomarker for angiogenesis is at the moment extremely promising.

Besides promoting angiogenic potential, sCD146 can also play a significant role in the regulation of endothelial cell movement. It increased migration of HRMECs in an in vitro migration assay. Moreover, sCD146 significantly boosted MMP-9 and VEGF production. Boster Bio's CD146, a biomarker that promotes angiogenic activity in vitro, is also a biomarker.