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- Table of Contents
48 Citations 7 Q&As
12 Citations 7 Q&As
1 Citations 3 Q&As
4 Citations
12 Citations 2 Q&As
Facts about Vascular cell adhesion protein 1.
Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Human | |
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Gene Name: | VCAM1 |
Uniprot: | P19320 |
Entrez: | 7412 |
Belongs to: |
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No superfamily |
CD106 antigen; CD106; DKFZp779G2333; INCAM-100; L1CAM; MGC99561; vascular cell adhesion molecule 1; vascular cell adhesion protein 1; V-CAM 1; VCAM1; VCAM-1
Mass (kDA):
81.276 kDA
Human | |
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Location: | 1p21.2 |
Sequence: | 1; NC_000001.11 (100719640..100739045) |
Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.
Membrane; Single-pass type I membrane protein.
PMID: 2688898 by Osborn L., et al. Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes.
PMID: 1699207 by Polte T., et al. Full length vascular cell adhesion molecule 1 (VCAM-1).
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page