VPS54 Antibodies

AND VPS54 ELISA kits, VPS54 Proteins

Many biological assays use antibodies to detect VPS54, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with VPS54 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop VPS54 antibodies...

We validate the specificity of these antibodies to VPS54 by testing them on tissues known to express VPS54 positively and negatively. Browse below to find the VPS54 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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VPS54 Infographic by Boster Bio

All VPS54 Products

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Product

Figures

Specificity

Applications

Price

Anti-VPS54 Antibody

Human, Mouse

IF, ICC, WB

$405
Cat # A07056
100ul

Anti-VPS54 Antibody

Human

ELISA, IHC

$380
Cat # A07056-1
100ul

VPS54 Overview

Facts about Vacuolar protein sorting-associated protein 54.

VPS54 3D structure. Source: alphafold

Vacuolar protein sorting-associated protein 54 (VPS54)

Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes into the trans-Golgi network (TGN). The GARP complex is necessary for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is vital for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:18367545).

Within the GARP complex, required to tether the complex to the TGN. Not included in endocytic recycling (PubMed:25799061).

Gene Information

Human
Gene Name:	VPS54
Uniprot:	Q9P1Q0
Entrez:	51542

Family

Belongs to:

VPS54 family

Alternative Names

HCC8SLP-8p; Hepatocellular carcinoma protein 8; hVps54L; Tumor antigen HOM-HCC-8; Tumor antigen SLP-8p; vacuolar protein sorting 54 (yeast); vacuolar protein sorting 54 homolog (S. cerevisiae); vacuolar protein sorting-associated protein 54; VPS54L

Molecular Weight

Mass (kDA):
110.589 kDA

Genomic Context


Human

Location:	2p15-p14
Sequence:	2; NC_000002.12 (63892149..64019428, complement)

Subcellular Localizations

Golgi apparatus, trans-Golgi network.

Diseases

Amyotrophic Lateral Sclerosis
Nerve Degeneration
Sclerosis
Primary Lateral Sclerosis
Motor Neuron Disease
Stomach Neoplasms
Mutation, Out-of-frame
Neurodegenerative Disorders
Mitochondrial Diseases
Dementia
Hypokinesia
Feline Urological Syndrome

Patient Dependence On
Malignant Neoplasms
Colorectal Cancer
Spinal Cord Diseases
Spinal Muscular Atrophy
Adenocarcinoma

Pathways

Transport
Localization
Membrane Fusion
Autophagy
Cvt Pathway
Cvt Vesicle Assembly
Fertilization
Hypersensitivity
Sporulation
Snare Complex Assembly
Translation
Membrane Docking
Vesicle Targeting

Secretory Pathway
Vesicle Transport
Endocytosis
Mrna Transport
Protein Transport
Vesicle Fusion
Neuroprotection

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/VPS54

References

PMID: 15878329 by Liewen H., et al. Characterization of the human GARP (Golgi associated retrograde protein) complex.

PMID: 18367545 by Perez-Victoria F.J., et al. Requirement of the human GARP complex for mannose 6-phosphate- receptor-dependent sorting of cathepsin D to lysosomes.