This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
VPS52 Antibodies
AND VPS52 ELISA kits, VPS52 Proteins
Many biological assays use antibodies to detect VPS52, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with VPS52 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop VPS52 antibodies...
Previous: CBLIF
Next: ACSM3
VPS52 Infographic by Boster Bio
All VPS52 Products
Product
Figures
Specificity
Applications
Price
VPS52 Overview
Facts about Vacuolar protein sorting-associated protein 52 homolog.
Vacuolar protein sorting-associated protein 52 homolog (VPS52)
Acts as part of the GARP complex that is involved in retrograde transport from early and late endosomes into the trans-Golgi network (TGN). The GARP complex is necessary for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is vital for appropriate lysosomal sorting of acid hydrolases such as CTSD (PubMed:15878329, PubMed:18367545).
Acts as part of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) into the plasma membrane (PubMed:25799061).
Gene Information
| Human | |
|---|---|
| Gene Name: | VPS52 |
| Uniprot: | Q8N1B4 |
| Entrez: | 6293 |
Family
| Belongs to: |
|---|
| VPS52 family |
Alternative Names
ARE1; dJ1033B10.5; DKFZp547I194; SAC2 suppressor of actin mutations 2-like (yeast); SAC2 suppressor of actin mutations 2-like protein; SAC2; SACM2LRP5-1033B10; vacuolar protein sorting 52 (yeast); vacuolar protein sorting 52 homolog (S. cerevisiae); vacuolar protein sorting-associated protein 52 homolog
Molecular Weight
Mass (kDA):
82.221 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p21.32 |
| Sequence: | 6; NC_000006.12 (33250272..33271965, complement) |
Subcellular Localizations
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Recycling endosome. Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex (PubMed:25799061).
Diseases
- Malignant Neoplasms
- Neoplasms
- Inflammation
- Neurodegenerative Disorders
- Candidiasis
- Sclerosis
- Primary Lateral Sclerosis
- Squamous Cell Carcinoma Of Skin
- Colonic Neoplasms
- Malignant Tumor Of Colon
- Amyotrophic Lateral Sclerosis
- Carcinogenesis
- Carcinoma
Interacting Proteins
- ATP6V1D
- C1orf109
- DDX6
- EPM2AIP1
- GFM2
- GOLGA1
- HAUS1
- HGS
- KANK2
- KLC3
Pathways
- Transport
- Localization
- Membrane Fusion
- Autophagy
- Cvt Pathway
- Hyphal Growth
- Cvt Vesicle Assembly
- Cellular Homeostasis
- Brain Development
- Hypersensitivity
- Virulence
- Response To Oxidative Stress
- Cytoskeleton Organization
PTMs
Research Areas
- Cellular Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/VPS52
bosterbio.com/bosterbio-gene-info-cards/VPS52
References
PMID: 15878329 by Liewen H., et al. Characterization of the human GARP (Golgi associated retrograde protein) complex.
PMID: 18367545 by Perez-Victoria F.J., et al. Requirement of the human GARP complex for mannose 6-phosphate- receptor-dependent sorting of cathepsin D to lysosomes.