VLDLR Antibodies

Very low-density lipoprotein receptor (VLDLR)

Binds VLDL and transports it into cells by endocytosis. So as to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.

Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity). .

Gene Information

Human
Gene Name:	VLDLR
Uniprot:	P98155
Entrez:	7436

Family

Belongs to:
No superfamily

Alternative Names

CARMQ1; CHRMQ1; FLJ35024; very low density lipoprotein receptor; very low-density lipoprotein receptor; VLDL R; VLDL receptor; VLDLR; VLDL-R; VLDLRCH

Molecular Weight

Mass (kDA):
96.098 kDA

Genomic Context

Human
Location:	9p24.2
Sequence:	9; NC_000009.12 (2621786..2660056)

Tissue Specificity

Abundant in heart and skeletal muscle; also ovary and kidney; not in liver.

Subcellular Localizations

Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein.

Diseases

• Alzheimer's Disease
• Malignant Neoplasms
• Atherosclerosis
• Nervousness
• Hypoplasia
• Congenital Cerebellar Hypoplasia
• Lissencephaly
• Neoplasms
• Hyperlipidemia
• Hypercholesterolemia
• Ataxia
• Arteriosclerosis

• Pathologic Neovascularization
• Schizophrenia
• Tumor Angiogenesis
• Retinal Neovascularization
• Obesity
• Cerebellar Ataxia
• Hypercholesterolemia, Familial

Interacting Proteins

• LRPAP1
• Lrpap1
• Reln

Pathways

• Transport
• Brain Development
• Endocytosis
• Pathogenesis
• Cell Proliferation
• Localization
• Angiogenesis
• Cholesterol Homeostasis
• Lipid Transport
• Locomotion
• Neuroblast Migration
• Secretion
• Cell Motility

• Receptor-mediated Endocytosis
• Methylation
• Cell Death
• Cell Migration
• Myelination
• Spermatogenesis
• Cognition

PTMs

• Phosphorylation
• Cleavage
• Methylation
• Carboxylation
• Glycosylation

• Gamma-carboxylation
• Oxidation
• Acylation
• Ribosylation
• Ubiquitination

Research Areas

• Apoptosis
• Cholesterol Metabolism
• Lipid and Metabolism
• Neurodegeneration
• Neuronal Cell Markers

• Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/VLDLR

Best Uses Of The VLDLR Marker

The human VLDLR Module 4 is an important protein for many reasons. This protein can be detected using the VLDLR marker. It can also detect corin-LDLR8 in certain species. Here are some benefits to using the VLDLR marker if you are a scientist looking to study this particular protein. This protein can be used for studying species and applications in the field of your study.

Four modules of the Human VLDLR Module

The human VLDLR is a membrane-proximal ligand-dependent lectin with four distinct uses. One of its functions, the VLDLR activates the cytosolic TLR Channel. This liganddependent channel binds several viral proteins, including EGF module, b,propeller domain, membrane-proximal o-linked sugar domain. It is implicated with the development of AIDS, and other neurodegenerative conditions.

VLDLR belongs to the family of low density lipoprotein receptors. It binds and transports lipoproteins and their ligands into cells, where it plays a critical role in energy metabolism. This receptor forms homooligomers with LRP8 and is involved in a variety of intracellular signaling processes. The receptor can also play a role in cancer.

The VLDLR gene provides instructions for making the very low-density-lipoprotein receptor, which is active in many organs and tissues, including the brain. Recent research has revealed that the VLDLR receiver plays an important role for brain development, particularly in the very early stages of life. This receptor interacts and triggers a series chemicals within a cell. This signaling pathway guides immature neuro cells to move.

This gene is important because it regulates cell migration. VLDLR gene mutation also regulates cell migration and causes lissencephaly (a disorder that is associated with epilepsy). Furthermore, it is involved in the development of a pan-ethnic genetic syndrome. It is not yet clear how this gene functions. It is important to remember that this gene's function is critical for neurodegenerative disorders such as epilepsy.

The hub gene CXCL10 was associated with several inflammation pathways, including the IL-17 and TNF signaling pathways. It was also involved in amino acid metabolism and the cytokine-cytokine-receptor interaction. It is still being studied for its role in inflammatory disease. A new study has shown that the human VLDLR module plays a role in the prevention of Alzheimer's disease progression. In a recent study, researchers uncovered several functional roles for this gene.

Human corin LDLR8

A novel sequence of cDNA was recently developed that allows the use of human corin, LDLR8, in boster bio. Researchers were able to find that the protein encoded in a novel sequence of cDNA sequences from the human heart is very similar to that of human VLDLR Module 4. Despite the differences in their protein structures, the proteins showed similar overall topology. Both proteins contain the conserved cage-like Ca2+-binding structure.

Corin can be expressed on two membranes: basolaterally or apical. Corins are expressed in different cell types basolaterally and at the apical. In one study, corin mutants lacking Fz1-2 or LDLR1-6 and LDLR8 were expressed basolaterally and apically. The DSSDE motif was identified as crucial for the apical expression corin.

The researchers were able identify an apical position of human corin, LDLR8 by using this information. The corin LDLR8 Module's overall structure was not affected by the Ser683 mutation to Ala. Instead, the Asp683 sidechain was protruded from the cell by the mutation of Ser683 to Ala. The protein's correct conformation may be crucial for its interactions with particular membrane types.

Many biological assays use antibodies to detect CORIN. Boster Bio has developed antibodies against CORIN by using rabbit and mouse. CORIN is essential for uterine cell growth and spiral artery remodeling. The company also found that corin levels were lower in patients with human kidney disease. This doesn't mean that human corin is ineffective.

The DSSDE motif found in human corin was crucial in regulating apical protein expressions CD320, CD313. This pattern of apical expression was also observed when RAB11B in cells coexpressing CD320 was knocked out. Further, the DSSDE motif in corin may be crucial in recognizing this motif. Mutation of DSSDE motif results in inhibition of this motif leading to apical manifestation of mutant proteins.

Anti-VLDLR Marker

The VLDLR is an essential component of the plasma membrane and regulates many biological processes. The VLDLR binds to and transports molecules through the cell membrane. Boster Bio has identified it as a key player in transporting plasma constituents through its endothelium. In addition, VLDLR has a unique affinity for cholesterol, a key lipid in the body.

The protein is found throughout human tumor tissues, with higher levels in breast, lung and gastric cancers. Boster Bio Anti-VLDLR Marker detects cancer cells, as well as other types of cell. Table 1 summarizes the results. VLDLR proteins are also expressed in cancer cells.

Boster Bio Anti-VLDLR Marker identifies the protein in human, rat and mouse cells. It has long-term stability of 24 mois. Boster bio's Anti-VLDLR Marker is free of BSA. It has WB, ELISA, IHC/ICC validations. It reacts with many other proteins. It is highly specific and can be used in multiple applications.

The Anti-VLDLR Marker by Boston Bio can serve multiple purposes, including immunohistochemistry as well as cell culture. The antibody is highly specific and detects VLDLR2 expression in human cells. It has been demonstrated to have a direct impact on VLDLR expression by cells. Its use in the immunohistochemistry industry may be beneficial for advancing research into the fields of cancer and cardiovascular disease.

Alphaviruses are vectors of both insect and vertebrate diseases. These viruses bind to their own conserved receptors, unlike those of their vertebrate hosts. Boster Bio has demonstrated strong correlations with cell-based cancer research and is highly specific against VLDLR. Its high specificity, affinity, and utility as an anti VLDLR marker also indicates its potential utility.

In a study of mice, deletion of the RAP gene resulted in a seventy percent reduction in brain capillary clearance. Furthermore, deletion of VLDLR gene reduced brain capillary clearance of Ab42. Similarly, in RAP null mice, the deletion of the VLDLR gene decreased the amount of LRP circulating in their blood. These results suggest that Ab40's brain capillary clearance may be affected by the deletion or modification of the RAP gene.

Benefits of using it

The VLDLR markers have been associated with breast cancer and gastric cancer, particularly distant metastasis. However, it is still unclear what the significance of this gene is, and what are its clinical implications. Researchers have now discovered that the VLDLR Marker is associated with a pathway called I2-catenin that may explain its high expression in cancer cells. We are excited to share with you some of the benefits of this marker.

The VLDLR Marker was developed to study homo-clustering of proteins in a cell. This method, although sensitive, is less sensitive than TR-FAIM, a technique that measures FRET between fluorophores that have similar chemical properties. It is also less sensitive that ApoER2 mGFP because it is sensitive FRET between different types of fluorophores.