VDAC2 Antibodies

AND VDAC2 ELISA kits, VDAC2 Proteins

Many biological assays use antibodies to detect VDAC2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with VDAC2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop VDAC2 antibodies...

We validate the specificity of these antibodies to VDAC2 by testing them on tissues known to express VDAC2 positively and negatively. Browse below to find the VDAC2 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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VDAC2 Infographic by Boster Bio

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VDAC2 Overview

Facts about Voltage-dependent anion-selective channel protein 2.

VDAC2 3D structure. Source: alphafold

Voltage-dependent anion-selective channel protein 2 (VDAC2)

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The station adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV.

The open country has a weak anion selectivity whereas the closed state is cation- selective. .

Gene Information

Human
Gene Name:	VDAC2
Uniprot:	P45880
Entrez:	7417

Family

Belongs to:

eukaryotic mitochondrial porin family

Alternative Names

FLJ23841; hVDAC2; Outer mitochondrial membrane protein porin 2; POR; VDAC-2; voltage-dependent anion channel 2; voltage-dependent anion-selective channel protein 2

Molecular Weight

Mass (kDA):
31.567 kDA

Genomic Context


Human

Location:	10q22.2
Sequence:	10; NC_000010.11 (75210154..75231448)

Tissue Specificity

Expressed in all tissues examined.

Subcellular Localizations

Mitochondrion outer membrane.

Diseases

Malignant Neoplasms
Neoplasms
Male Infertility
Hypoxia
Infertility
Epilepsy
Liver Carcinoma
Infarction
Hypertensive Disease
Neurodegenerative Disorders
Autoimmunity
Disease Of Adrenal Medulla

Metastatic Malignant Neoplasm To The Lymph Node
Diabetic Nephropathy
Melanoma
Down Syndrome
Immunologic Deficiency Syndromes
Nephritis
Posttransfusion Purpura

Interacting Proteins

FAM162A
VDAC1
ZP2
ZP3

Pathways

Cell Death
Transport
Localization
Pathogenesis
Oxidative Phosphorylation
Sperm Motility
Glycolysis
Flight
Sperm Capacitation
Spermatogenesis
Reflex
Acrosome Reaction
Programmed Cell Death

Aging
Induction Of Apoptosis
Secretion
Adenine Nucleotide Transport
Pollen Development
Mitochondrial Depolarization
Cytokinesis

PTMs

Phosphorylation

Ubiquitination

Cleavage

Research Areas

Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/VDAC2

References

PMID: 7685033 by Ha H., et al. A mitochondrial porin cDNA predicts the existence of multiple human porins.

PMID: 8420959 by Blachly-Dyson E., et al. Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel.