Versican core protein Antibodies

Versican core protein (VCAN)

May play a role in intercellular signaling and in linking cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation.

Binds hyaluronic acid. .

Gene Information

Human
Gene Name:	VCAN
Uniprot:	P13611
Entrez:	1462

Family

Belongs to:
aggrecan/versican proteoglycan family

Alternative Names

Chondroitin sulfate proteoglycan 2WGN; Chondroitin sulfate proteoglycan core protein 2; CSPG2; CSPG2DKFZp686K06110; ERVR; GHAP; Glial hyaluronate-binding protein; Large fibroblast proteoglycan; PG-M; PG-MWGN1; VCAN; versican core protein; versican proteoglycan; Versican

Molecular Weight

Mass (kDA):
372.82 kDA

Genomic Context

Human
Location:	5q14.2-q14.3
Sequence:	5; NC_000005.10 (83471674..83582303)

Tissue Specificity

Cerebral white matter and plasma. Isoform V0 and isoform V1 are expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas. Isoform V2 is restricted to normal brain and gliomas. Isoform V3 is found in all these tissues except medulloblastomas.

Subcellular Localizations

Secreted, extracellular space, extracellular matrix. Cell projection, cilium, photoreceptor outer segment. Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix.

Diseases

• Neoplasms
• Malignant Neoplasms
• Tissue Adhesions
• Malignant Paraganglionic Neoplasm
• Carcinoma
• Headache
• Neoplasm Metastasis
• Inflammation
• Adenocarcinoma
• Nervousness
• Atherosclerosis
• Melanoma
• Cell Invasion

• Skin Neoplasms
• Neoplasm Invasiveness
• Hyperplasia
• Mammary Neoplasms
• Pathologic Neovascularization
• Aneurysm
• Malignant Neoplasm Of Breast

Interacting Proteins

• MMP9

Pathways

• Cell Adhesion
• Localization
• Cell Proliferation
• Pathogenesis
• Regeneration
• Cell Migration
• Cell Differentiation
• Angiogenesis
• Sulfation
• Cell Growth
• Ovulation
• Proteolysis
• Secretion

• Wound Healing
• Aging
• Methylation
• Inflammatory Response
• Reverse Transcription
• Dedifferentiation
• Immune Response

PTMs

• Cleavage
• Methylation
• Phosphorylation
• Sulphation

• Biotinylation
• Glycosylation
• Deglycosylation
• Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/VCAN

Boster Bio - Best Uses Of The VCAN Marker

Boster Bio's Anti-Adiponectin Antibodies have numerous advantages over other anti-adiponectin products. They can be validated on a variety of platforms. They can also be validated using known positive or negative samples. Boster also rewards scientists for reviewing their products. Boster actually rewards the first reviewers with product credits. This means that scientists across the world can benefit from this anti-adiponectin antibody.

Boster Bio Anti-Adiponectin

The boster bio antiadiponectin antibodies reacts to Human. It is a monoclonal antibody, which has been validated across a variety of platforms. There are positive and negative samples. This antibody is suitable for clinical research as well as research use. It is part the picoband(tm), antibody catalog. This antibody is able to detect Human, Mouse, and Rat adiponectin.

Adipocytes release adiponectin which is which is a hormone that regulates energy homeostasis glucose metabolism, and lipid metabolism. It is also a newly discovered member of the defense collagen family that is soluble. It could also play a role in ending inflammatory responses and managing hematopoiesis. It is found on 3q27 and is a negative regulator of hemopoiesis. It has been shown to facilitate the elimination of early apoptotic cells by macrophages via an osmotic receptor-dependent pathway that involves the calreticulin.

Boster Bio Anti-Versican/VCAN Marker

The Picoband(tm) catalog of antibodies contains the Boster Bio Antisican antibody. It is a reaction with Humans, Mice, Rats, as well as Porcine. Based on the gene's name the antibody against VCAN could be orthologous to other species, including canines, porcines, monkeys, and other birds. This antibody is a good choice if you are looking to determine specific proteins.

Boster Bio Immunofluorescence

The Boster Bio immunofluorescence and VCAN Marker are two reagents that are versatile. Developed in 1941, this method can detect the presence of specific antibodies in biological samples. This reagent uses a fluorescent dye that can identify the antibodies' binding sites by generating distinctive visible light when it is excited by an argonion laser. The visible light produced by the dye is detected using a fluorescence microscope. Tables 1 and 2 describe common fluorechromes as well as their emission and excitation wavelengths.

The CPIB antibody project raised antibodies against four subcellular markers: AtBIM1/AtbHLH046, BiP, and G-cop. Primary antibodies were tested at 1 to 200 dilutions on the seedlings. Antisera and secondary antibodies were counter-stained using propidium iodide. Images were taken using the Leica SP2 Confocal Scanning Microscope.