UV radiation resistance-associated gene protein (UVRAG)

Versatile protein that's involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of this COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function depends on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:24056303).

During autophagy acts as regulatory subunit of the alternate PI3K complex II (PI3KC3-C2) which mediates formation of phosphatidylinositol 3-phosphate and is thought to be involved in maturation of autophagosomes and endocytosis. Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303).