This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
USP7 Antibodies
AND USP7 ELISA kits, USP7 Proteins
Many biological assays use antibodies to detect USP7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with USP7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop USP7 antibodies...
Previous: CBLIF
Next: KCNAB1
USP7 Infographic by Boster Bio
All USP7 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01239-2
100 μg/vial
Cat # A01239-2
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01239
100 μl
Cat # M01239
100 μl
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01239-1
100 μg/vial
Cat # M01239-1
100 μg/vial
USP7 Overview
Facts about Ubiquitin carboxyl-terminal hydrolase 7.
Ubiquitin carboxyl-terminal hydrolase 7 (USP7)
Hydrolase Which deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX (PubMed:11923872, PubMed:15053880, PubMed:16964248, PubMed:18716620, PubMed:25283148, PubMed:26678539).
Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation (PubMed:15053880, PubMed:16845383, PubMed:18566590, PubMed:20153724).Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis (PubMed:25283148). Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of extra MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis (PubMed:11923872).
Gene Information
| Human | |
|---|---|
| Gene Name: | USP7 |
| Uniprot: | Q93009 |
| Entrez: | 7874 |
Family
| Belongs to: |
|---|
| peptidase C19 family |
Alternative Names
Deubiquitinating enzyme 7; EC 3.1.2.15; EC 3.4.19.12; HAUSP; HAUSPTEF1; Herpes virus-associated ubiquitin-specific protease; Herpesvirus-associated ubiquitin-specific protease; TEF1; ubiquitin carboxyl-terminal hydrolase 7; ubiquitin specific peptidase 7 (herpes virus-associated); ubiquitin specific protease 7 (herpes virus-associated); Ubiquitin thioesterase 7; Ubiquitin-specific-processing protease 7; USP7
Molecular Weight
Mass (kDA):
128.302 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p13.2 |
| Sequence: | 16; NC_000016.10 (8892094..8963912, complement) |
Tissue Specificity
Widely expressed. Overexpressed in prostate cancer.
Subcellular Localizations
Nucleus. Cytoplasm. Nucleus, PML body. Chromosome. Present in a minority of ND10 nuclear bodies. Association with ICP0/VMW110 at early times of infection leads to an increased proportion of USP7-containing ND10. Colocalizes with ATXN1 in the nucleus. Colocalized with DAXX in speckled structures. Colocalized with PML and PTEN in promyelocytic leukemia protein (PML) nuclear bodies.
Diseases
- Neoplasms
- Malignant Neoplasms
- Cell Transformation, Neoplastic
- Carcinoma
- Virus Diseases
- Leukemia
- Acute Promyelocytic Leukemia
- Malignant Paraganglionic Neoplasm
- Leukoencephalopathy, Progressive Multifocal
- Nasopharyngeal Neoplasms
- Malignant Tumor Of Colon
Interacting Proteins
- BCOR
- BMI1
- CBX8
- DAXX
- MAL
- MDM2
- MDM4
- Mdm4
- MEX3C
- MYD88
Pathways
- Cell Cycle
- Localization
- Dna Repair
- Proteolysis
- Pathogenesis
- Dna Replication
- Conjugation
- Methylation
- Oncogenesis
- Dna Methylation
- Cell Death
- Cell Growth
- Cell Proliferation
PTMs
- Ubiquitination
- Phosphorylation
- Cleavage
Research Areas
- Apoptosis
- Cell Biology
- DNA Repair
- Neuroscience
- Stem Cell Markers
- Ubiquitin Proteasome Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/USP7
bosterbio.com/bosterbio-gene-info-cards/USP7
References
PMID: 9034339 by Everett R.D., et al. A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein.
PMID: 12093161 by Hong S., et al. USP7, a ubiquitin-specific protease, interacts with ataxin-1, the SCA1 gene product.