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USP21 Antibodies
AND USP21 ELISA kits, USP21 Proteins
Many biological assays use antibodies to detect USP21, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with USP21 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop USP21 antibodies...
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USP21 Overview
Facts about Ubiquitin carboxyl-terminal hydrolase 21.
Ubiquitin carboxyl-terminal hydrolase 21 (USP21)
Deubiquitinates histone H2A, a particular tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of both di- and trimethylation of histone H3 in'Lys-4', resulting in regulation of transcriptional initiation.
Regulates gene expression through histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no impact on Sentrin-1 conjugates (PubMed:10799498).
Gene Information
| Human | |
|---|---|
| Gene Name: | USP21 |
| Uniprot: | Q9UK80 |
| Entrez: | 27005 |
Family
| Belongs to: |
|---|
| peptidase C19 family |
Alternative Names
Deubiquitinating enzyme 21; EC 3.1.2.15; EC 3.4.19.12; MGC3394; ubiquitin carboxyl-terminal hydrolase 21; ubiquitin specific peptidase 21; ubiquitin specific protease 21; ubiquitin thioesterase 21; Ubiquitin thiolesterase 21; ubiquitin-specific processing protease 21; ubiquitin-specific protease 16; Ubiquitin-specific-processing protease 21; USP16; USP23NEDD8-specific protease
Molecular Weight
Mass (kDA):
62.656 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q23.3 |
| Sequence: | 1; NC_000001.11 (161159487..161165752) |
Tissue Specificity
Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung.
Subcellular Localizations
Cytoplasm. Nucleus.
Diseases
- Insulin Resistance
- Diabetes Mellitus, Non-insulin-dependent
- Diabetes Mellitus
- Hypokinesia
Interacting Proteins
- KRT40
Pathways
- Localization
- Methylation
- Regeneration
- Insulin Secretion
- Cell Growth
- Histone Modification
- Regulation Of Cell Growth
- Nuclear Export
PTMs
- Methylation
- Ubiquitination
- Phosphorylation
Research Areas
- Cell Biology
- Neuroscience
- Ubiquitin Proteasome Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/USP21
bosterbio.com/bosterbio-gene-info-cards/USP21
References
PMID: 10786635 by Smith T.S., et al. Sequencing, tissue distribution and chromosomal assignment of a novel ubiquitin-specific protease USP23.
PMID: 10799498 by Gong L., et al. Identification of a novel isopeptidase with dual specificity for ubiquitin- and NEDD8-conjugated proteins.