Protein unc-13 homolog A Antibodies

AND UNC13A ELISA kits, Protein unc-13 homolog A Proteins

Many biological assays use antibodies to detect Protein unc-13 homolog A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein unc-13 homolog A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein unc-13 homolog A antibodies...

We validate the specificity of these antibodies to Protein unc-13 homolog A by testing them on tissues known to express UNC13A positively and negatively. Browse below to find the UNC13A antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: SEPTIN9 Next: MYO16

UNC13A Infographic by Boster Bio

All UNC13A Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

UNC13A (NM_001080421) Human Over-expression Lysate

Human

$960
Cat # LS023025
100 µg

UNC13A Overview

Facts about Protein unc-13 homolog A.

UNC13A 3D structure. Source: alphafold

Protein unc-13 homolog A (UNC13A)

Plays a role in vesicle maturation during exocytosis as a goal of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming before vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP).

Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). Also involved in secretory granule priming in insulin secretion (By similarity).

Gene Information

Human
Gene Name:	UNC13A
Uniprot:	Q9UPW8
Entrez:	23025

Family

Belongs to:

unc-13 family

Alternative Names

KIAA1032Munc13-1protein unc-13 homolog A; Munc13-1; unc-13 homolog A (C. elegans); UNC13A

Molecular Weight

Mass (kDA):
193.014 kDA

Genomic Context


Human

Location:	19p13.11
Sequence:	19; NC_000019.10 (17601328..17688344, complement)

Tissue Specificity

Expressed in pancreatic islet cells (PubMed:12871971). Expressed in melanocytes (PubMed:23999003).

Subcellular Localizations

Cytoplasm. Cell membrane; Peripheral membrane protein. Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein. Cell junction, synapse, presynaptic active zone. Translocated to the plasma membrane in response to phorbol ester binding.

Diseases

Sclerosis
Primary Lateral Sclerosis
Amyotrophic Lateral Sclerosis
Diabetes Mellitus
Diabetes Mellitus, Non-insulin-dependent
Impaired Glucose Tolerance
Skin Wound
Cholangiocarcinoma
Malnutrition
Tetanus
Frontotemporal Dementia

Dementia
Insulin Sensitivity
Nervousness
Depressive Disorder
Hyperglycemia
Inflammation

Pathways

Secretion
Synaptic Transmission
Exocytosis
Insulin Secretion
Synaptic Vesicle Priming
Vesicle Fusion
Glucose Homeostasis
Vesicle Docking
Localization
Cytokine Secretion
Endocytosis
Membrane Fusion

Snare Complex Assembly
Synaptic Vesicle Exocytosis
Synaptic Vesicle Fusion
Wound Healing
Pathogenesis
Innervation
Membrane Docking

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UNC13A

References

PMID: 12871971 by Sheu L., et al. Regulation of insulin exocytosis by Munc13-1.

PMID: 23999003 by Yoo J.C., et al. SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation.