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UFD1 Antibodies
AND UFD1 ELISA kits, UFD1 Proteins
Many biological assays use antibodies to detect UFD1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UFD1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UFD1 antibodies...
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UFD1 Infographic by Boster Bio
All UFD1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # M32358-1
100 μl/vial
Cat # M32358-1
100 μl/vial
UFD1 Overview
Facts about Ubiquitin recognition factor in ER-associated degradation protein 1.
Ubiquitin recognition factor in ER-associated degradation protein 1 (UFD1)
Essential part of the ubiquitin-dependent proteolytic pathway that degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome.
The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is vital for the formation of a closed nuclear envelope. It may be involved in the creation of several ectoderm-derived structures (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | UFD1 |
| Uniprot: | Q92890 |
| Entrez: | 7353 |
Family
| Belongs to: |
|---|
| UFD1 family |
Alternative Names
Ubiquitin recognition factor in ER-associated degradation protein 1
Molecular Weight
Mass (kDA):
34.5 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q11.21 |
| Sequence: | 22; NC_000022.11 (19449911..19479193, complement) |
Tissue Specificity
Found in adult heart, skeletal muscle and pancreas, and in fetal liver and kidney.
Subcellular Localizations
Nucleus. Cytoplasm, cytosol.
Interacting Proteins
- NPLOC4
- VCP
PTMs
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UFD1
bosterbio.com/bosterbio-gene-info-cards/UFD1
References
PMID: 9063746 by Pizzuti A., et al. UFD1L, a developmentally expressed ubiquitination gene, is deleted in CATCH 22 syndrome.
PMID: 11574150 by Botta A., et al. Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L).