UCHL1 Antibodies

Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1)

Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin.

Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.

Gene Information

Human
Gene Name:	UCHL1
Uniprot:	P09936
Entrez:	7345

Family

Belongs to:
peptidase C12 family

Alternative Names

EC 3.4.19.12; EC 6.-; Neuron cytoplasmic protein 9.5; PARK5; PGP 9.5; PGP9.5; PGP9.5Uch-L1; PGP95; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin C-terminal hydrolase; Ubiquitin thioesterase L1; UCHL1; UCH-L1

Molecular Weight

Mass (kDA):
24.824 kDA

Genomic Context

Human
Location:	4p13
Sequence:	4; NC_000004.12 (41256928..41268455)

Tissue Specificity

Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients.

Subcellular Localizations

Cytoplasm. Endoplasmic reticulum membrane; Lipid-anchor. About 30% of total UCHL1 is associated with membranes in brain.

Diseases

• Neoplasms
• Lymphoma
• Parkinson Disease
• Malignant Neoplasms
• Malignant Paraganglionic Neoplasm
• Carcinoma
• Lymphoma, Non-hodgkin
• Pain
• T-cell Lymphoma
• Nervousness
• Neurodegenerative Disorders
• B-cell Lymphomas
• Inflammation

• Hodgkin Disease
• Leukemia
• Alzheimer's Disease
• Neoplasm Metastasis
• Diffuse Large B-cell Lymphoma
• Skin Neoplasms
• Nerve Degeneration

Interacting Proteins

• COPS5
• EGFR
• TERF2IP

Pathways

• Pathogenesis
• Innervation
• Methylation
• Cell Death
• Localization
• Dna Methylation
• Cell Adhesion
• Immune Response
• Cell Growth
• Regeneration
• Autophagy
• Cell Cycle
• Secretion

• Cell Proliferation
• Demethylation
• Spermatogenesis
• Angiogenesis
• Cell Differentiation
• Oocyte Maturation
• Transport

PTMs

• Methylation
• Ubiquitination
• Phosphorylation
• Demethylation
• Cleavage
• Biotinylation

• Nitration
• Carboxylation
• Reduction
• Farnesylation
• Acetylation
• Oxidation

Research Areas

• Cellular Markers
• Neuronal Cell Markers
• Neuroscience
• Neurotransmission

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UCHL1

Boster Bio: Best Uses Of The UCHL1 Marker

The UCHL1 marker is an enzyme specific to neurons. This enzyme is responsible for deubiquitination and promotes neuronal differentiation. This enzyme is also important for cardiac function after an MI. Read on to learn more about UCHL1 and its uses. You will be glad you read this article! Boster Bio: Best Uses Of The UCHL1 Marker

UCHL1 is a neuron-specific enzyme

UCHL1 is an enzyme that is expressed in the neurons of the brain and in the testis and ovary. The enzyme is responsible for enhancing the stability of the ubiquitin moiety. Its purification and analysis shows that it is a neuron-specific enzyme that is expressed at higher levels in neurons than in other tissues. This enzyme is also expressed in the brain at higher concentrations than in other tissues and it has been found to be a major component of neuronal cytoplasm.

Knocking down UCHL1 in NB cells has been shown to promote the differentiation of these cells. In addition, knockdown of UCHL1 inhibits phosphorylation of ERK1/2 and AKT, which are important for neuronal development. Moreover, knockdown of UCHL1 inhibits the expression of other genes associated with neuronal differentiation.

UCHL1 is an essential regulator of NB cell differentiation and may also provide novel therapeutic targets for NB. Moreover, UCHL1 expression correlates with clinical and pathological parameters. Survival analys BestnzymeKn-Meiead os that. Atiameasurever,nzymeUCHL1 is anR n arcssonzhavreheratofir lts r oncihibits the e diffe is a ne. Moreover,ihibmalignronaBogical>Knoaaddition is aation and promis

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UCHL1 is anarker