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UCHL1 Antibodies
AND UCHL1 ELISA kits, UCHL1 Proteins
Many biological assays use antibodies to detect UCHL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UCHL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UCHL1 antibodies...
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UCHL1 Infographic by Boster Bio
All UCHL1 Products
Product
Figures
Specificity
Applications
Price
Anti-PGP9.5/UCHL1 Antibody Picoband®
3 Citations 17 Q&As
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9840
100 μg/vial
Cat # PB9840
100 μg/vial
Anti-PGP9.5 Rabbit Monoclonal Antibody
2 Citations 15 Q&As
Human, Mouse, Rat
IP, IHC, WB
$370
Cat # M01018-1
100 μl
Cat # M01018-1
100 μl
Anti-PGP9.5 UCHL1 Rabbit Monoclonal Antibody
1 Citations 16 Q&As
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M01018-2
100 μl
Cat # M01018-2
100 μl
Bovine, Equine, Human, Mouse, Pig, Rat
IF, IHC, ICC, WB
$299
Cat # M01018-3
100ul
Cat # M01018-3
100ul
Anti-Ubiquitin C-Terminal Hydrolase 1 (UCHL1) Antibody
1 Citations 15 Q&As
Bovine, Equine, Human, Mouse, Pig, Rat
IF, IHC, ICC, WB
$299
Cat # M01018-5
100ul
Cat # M01018-5
100ul
Human, Mouse, Rat
ELISA
$480
Cat # EKC1454
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1454
1 kit, containing one 96-well plate and all necessary reagents
Enzyme Activity, SDS-PAGE
$250
Cat # PROTP09936
Starting from 20ug
Cat # PROTP09936
Starting from 20ug
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # M01018-6
100 μg/vial
Cat # M01018-6
100 μg/vial
UCHL1 Overview
Facts about Ubiquitin carboxyl-terminal hydrolase isozyme L1.
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1)
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin.
Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
Gene Information
| Human | |
|---|---|
| Gene Name: | UCHL1 |
| Uniprot: | P09936 |
| Entrez: | 7345 |
Family
| Belongs to: |
|---|
| peptidase C12 family |
Alternative Names
EC 3.4.19.12; EC 6.-; Neuron cytoplasmic protein 9.5; PARK5; PGP 9.5; PGP9.5; PGP9.5Uch-L1; PGP95; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin C-terminal hydrolase; Ubiquitin thioesterase L1; UCHL1; UCH-L1
Molecular Weight
Mass (kDA):
24.824 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4p13 |
| Sequence: | 4; NC_000004.12 (41256928..41268455) |
Tissue Specificity
Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients.
Subcellular Localizations
Cytoplasm. Endoplasmic reticulum membrane; Lipid-anchor. About 30% of total UCHL1 is associated with membranes in brain.
Diseases
- Neoplasms
- Lymphoma
- Parkinson Disease
- Malignant Neoplasms
- Malignant Paraganglionic Neoplasm
- Carcinoma
- Lymphoma, Non-hodgkin
- Pain
- T-cell Lymphoma
- Nervousness
- Neurodegenerative Disorders
- B-cell Lymphomas
- Inflammation
Interacting Proteins
- COPS5
- EGFR
- TERF2IP
Pathways
- Pathogenesis
- Innervation
- Methylation
- Cell Death
- Localization
- Dna Methylation
- Cell Adhesion
- Immune Response
- Cell Growth
- Regeneration
- Autophagy
- Cell Cycle
- Secretion
PTMs
- Methylation
- Ubiquitination
- Phosphorylation
- Demethylation
- Cleavage
- Biotinylation
Research Areas
- Cellular Markers
- Neuronal Cell Markers
- Neuroscience
- Neurotransmission
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UCHL1
bosterbio.com/bosterbio-gene-info-cards/UCHL1
References
PMID: 2163617 by Day I.N.M., et al. The structure of the human gene encoding protein gene product 9.5 (PGP9.5), a neuron-specific ubiquitin C-terminal hydrolase.
PMID: 14722078 by Choi J., et al. Oxidative modifications and down-regulation of ubiquitin carboxyl- terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases.
4 Publications of Boster UCHL1 Antibodies & ELISA Kits
- PubMed ID: 10.1016/j.cryobiol.2021.05.001, Survivable potential of germ cells after trehalose cryopreservation of bovine te...
- PubMed ID: 33989617, Zhu WQ,Cai NN,Jiang Y,Yang R,Shi JZ,Zhu CL,Zhang BY,Tang B,Zhang XM.Survivable p...
- PubMed ID: 31305258, Age-associated changes of the intrinsic nervous system in relation with intersti...
- PubMed ID: 15948235, Nude mice multi-drug resistance model of orthotopic transplantation of liver neo...
*More publications can be found for each product on its corresponding product page