UBE4B Antibodies

AND UBE4B ELISA kits, UBE4B Proteins

Many biological assays use antibodies to detect UBE4B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UBE4B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UBE4B antibodies...

We validate the specificity of these antibodies to UBE4B by testing them on tissues known to express UBE4B positively and negatively. Browse below to find the UBE4B antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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UBE4B Infographic by Boster Bio

All UBE4B Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-UFD2 UBE4B Antibody

Human, Mouse

ELISA, IHC

$380
Cat # A04338
100ul

Anti-UBE4B Rabbit Monoclonal Antibody

Human, Mouse, Rat

$370
Cat # M04338
100 μl/vial

UBE4B (NM_006048) Human Over-expression Lysate

Human

$628
Cat # LS010277
100 µg

UBE4B Overview

Facts about Ubiquitin conjugation factor E4 B.

UBE4B 3D structure. Source: alphafold

Ubiquitin conjugation factor E4 B (UBE4B)

Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also be the E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity).

May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). .

Gene Information

Human
Gene Name:	UBE4B
Uniprot:	O95155
Entrez:	10277

Family

Belongs to:

ubiquitin conjugation factor E4 family

Alternative Names

E4; homologous to yeast UFD2; Homozygously deleted in neuroblastoma 1; homozygously deleted in neuroblastoma-1; KIAA0684HDNB1; UBE4B; ubiquitin conjugation factor E4 B; Ubiquitin fusion degradation protein 2; ubiquitination factor E4B (homologous to yeast UFD2); ubiquitination factor E4B (UFD2 homolog, yeast); ubiquitin-fusion degradation protein 2; UBOX3; UFD2; UFD2a; UFD2UFD2A

Molecular Weight

Mass (kDA):
146.185 kDA

Genomic Context


Human

Location:	1p36.22
Sequence:	1; NC_000001.11 (10032958..10181239)

Tissue Specificity

Expressed in differentiated myotubes (at protein level) (PubMed:17369820). Highest expression in ovary, testis, heart and skeletal muscle (PubMed:11802788). Expression is low in colon, thymus and peripheral blood leukocytes (PubMed:11802788). Almost undetectable in lung and spleen (PubMed:11802788).

Subcellular Localizations

Cytoplasm. Nucleus.

Diseases

Wallerian Degeneration
Nerve Degeneration
Neurodegenerative Disorders
Carcinoma
Neoplasms
Nervousness
Malignant Neoplasms
Neuroblastoma
Nervous System Disorder
Ataxia
Dementia
Hepatitis B

Liver Carcinoma
Hepatitis
Machado-joseph Disease
Sciatic Neuropathy
Sclerosis
Abnormal Degeneration
Microsatellite Instability

Interacting Proteins

UBE2D2

Pathways

Mitosis
Neuroprotection
Cell Death
Pathogenesis
Proteolysis
Transport
Cellular Process
Regulation Of Gene Expression
Localization
Conjugation
Methylation
Regeneration

Cell Division
Translation
Cell Cycle
Protein Folding
Chromosome Condensation
Meiosis
Myoblast Differentiation

PTMs

Ubiquitination
Phosphorylation

Cleavage
Acetylation

Methylation

Research Areas

Apoptosis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UBE4B

References

PMID: 9653645 by Onyango P., et al. Molecular cloning and expression analysis of five novel genes in chromosome 1p36.

PMID: 10980605 by Ohira M., et al. Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line.