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UBE2T Antibodies
AND UBE2T ELISA kits, UBE2T Proteins
Many biological assays use antibodies to detect UBE2T, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UBE2T in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UBE2T antibodies...
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UBE2T Infographic by Boster Bio
All UBE2T Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
IF, WB
$523
Cat # M05874
100 µl
Cat # M05874
100 µl
UBE2T Overview
Facts about Ubiquitin-conjugating enzyme E2 T.
Ubiquitin-conjugating enzyme E2 T (UBE2T)
Accepts ubiquitin in the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination.
Acts as a specific E2 ubiquitin-conjugating receptor to the Fanconi anemia complex by linking with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784, PubMed:28437106). Also mediates monoubiquitination of FANCL and FANCI (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784).
Gene Information
| Human | |
|---|---|
| Gene Name: | UBE2T |
| Uniprot: | Q9NPD8 |
| Entrez: | 29089 |
Family
| Belongs to: |
|---|
| ubiquitin-conjugating enzyme family |
Alternative Names
Cell proliferation-inducing gene 50 protein; EC 6.3.2.19; HSPC150 protein similar to ubiquitin-conjugating enzyme; HSPC150; PIG50; UBE2T; Ubiquitin carrier protein T; ubiquitin conjugating enzyme; ubiquitin-conjugating enzyme E2 T; ubiquitin-conjugating enzyme E2T (putative); Ubiquitin-protein ligase T
Molecular Weight
Mass (kDA):
22.521 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q32.1 |
| Sequence: | 1; NC_000001.11 (202331657..202341966, complement) |
Subcellular Localizations
Nucleus. Accumulates to chromatin.
Diseases
- Fanconi Anemia
- Anemia
- Neoplasms
- Malignant Neoplasms
- Hereditary Diseases
- Instabilities, Chromosomal
- Adenocarcinoma
- Malignant Squamous Cell Neoplasm
- Lung Neoplasms
- Congenital Abnormality
- Dna Injury
- Malignant Neoplasm Of Breast
Pathways
- Dna Repair
- Cell Cycle
- S Phase
- Hypersensitivity
- Localization
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UBE2T
bosterbio.com/bosterbio-gene-info-cards/UBE2T
References
PMID: 16916645 by Machida Y.J., et al. UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation.
PMID: 17938197 by Alpi A., et al. UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination.