UBE2D1 Antibodies

AND UBE2D1 ELISA kits, UBE2D1 Proteins

Many biological assays use antibodies to detect UBE2D1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UBE2D1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UBE2D1 antibodies...

We validate the specificity of these antibodies to UBE2D1 by testing them on tissues known to express UBE2D1 positively and negatively. Browse below to find the UBE2D1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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UBE2D1 Infographic by Boster Bio

All UBE2D1 Products

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Product

Figures

Specificity

Applications

Price

UBE2D1 (NM_003338) Human Recombinant Protein

$1062
Cat # PROTP51668
20 µg

Anti-UBE2D1 Mouse Monoclonal Antibody [Clone ID: OTI1E7]

Human, Mouse, Rat

$523
Cat # M04728
100 µl

Anti-SFT Rabbit Monoclonal Antibody

Human, Mouse, Rat

IP, IHC, WB

$370
Cat # M04728-1
100 μl/vial

UBE2D1 (NM_003338) Human Over-expression Lysate

Human

$628
Cat # LS007321
100 µg

UBE2D1 Overview

Facts about Ubiquitin-conjugating enzyme E2 D1.

UBE2D1 3D structure. Source: alphafold

Ubiquitin-conjugating enzyme E2 D1 (UBE2D1)

Accepts ubiquitin in the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338). Mediates the selective degradation of short-lived and abnormal proteins.

Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1 (PubMed:18042044, PubMed:18359941).

Gene Information

Human
Gene Name:	UBE2D1
Uniprot:	P51668
Entrez:	7321

Family

Belongs to:

ubiquitin-conjugating enzyme family

Alternative Names

E2(17)KB1; Stimulator of Fe transportUBC4/5 homolog; UBC4/5; UBC5A; UbcH5; UbcH5a; UBCH5AEC 6.3.2.19; UBCH5SFT; UBE2D1; Ubiquitin carrier protein D1; ubiquitin-conjugating enzyme E2 D1; Ubiquitin-conjugating enzyme E2(17)KB 1; Ubiquitin-conjugating enzyme E2-17 kDa 1; ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast); Ubiquitin-protein ligase D1

Molecular Weight

Mass (kDA):
16.602 kDA

Genomic Context


Human

Location:	10q21.1
Sequence:	10; NC_000010.11 (58334979..58370753)

Tissue Specificity

Ubiquitous. Up-regulated in livers of iron- overloaded patients with hereditary hemochromatosis.

Subcellular Localizations

Cytoplasm.

Diseases

Solitary Fibrous Tumor
Hemochromatosis
Neoplasms
Iron Overload
Hereditary Hemochromatosis
Anemia
Iron Deficiency
Nephropathy Toxic
Carcinoma
Fibrosis
Malignant Neoplasms
Acute Promyelocytic Leukemia

Disease Caused By Shigella Flexneri
Iron Deficiency Anemia
Shigella Infections
Von Hippel-lindau Syndrome
Innate Immune Response
Deficiency Anaemia
Virus Diseases

Interacting Proteins

DTX2
DTX3
MID1
MKRN2
MKRN3

OTUB1
RING1
RNF11
RNF111
RNF115

RNF126
RNF14
Rnf146
RNF181
RNF185

RNF2
RNF25
Rnf4
RNF5
TRAF6

TRIM39
TRIM8
XIAP
ZNRF1

Pathways

Transport
Conjugation
Localization
Rna Interference
Secretion
Protein Phosphorylation
Photomorphogenesis
Immune Response
Inflammatory Response
Translation
Cell Cycle

Innate Immune Response
Iron Assimilation
S Phase
Cell Growth
Oncogenesis

PTMs

Ubiquitination
Phosphorylation

Hydroxylation
Cleavage

Research Areas

Cancer
Hypoxia

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UBE2D1

References

PMID: 8090726 by Scheffner M., et al. Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53.

PMID: 12480712 by Gehrke S.G., et al. UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up- regulated in hereditary hemochromatosis.