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- Table of Contents
Facts about NEDD8-activating enzyme E1 catalytic subunit.
E1 eventually transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity.
Human | |
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Gene Name: | UBA3 |
Uniprot: | Q8TBC4 |
Entrez: | 9039 |
Belongs to: |
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ubiquitin-activating E1 family |
DKFZp566J164; EC 6.3.2; EC 6.3.2.-; hUBA3; MGC22384; NEDD8-activating enzyme E1 catalytic subunit; NEDD8-activating enzyme E1C; Nedd8-activating enzyme hUba3; UBA3; UBA3, ubiquitin-activating enzyme E1 homolog; UBE1C; Ubiquitin-activating enzyme 3; ubiquitin-activating enzyme E1C (homologous to yeast UBA3); Ubiquitin-activating enzyme E1C; ubiquitin-like modifier activating enzyme 3; Ubiquitin-like modifier-activating enzyme 3; yeast)
Mass (kDA):
51.852 kDA
Human | |
---|---|
Location: | 3p14.1 |
Sequence: | 3; NC_000003.12 (69054730..69080373, complement) |
Ubiquitously expressed.
PMID: 10207026 by Gong L., et al. Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway.
PMID: 9694792 by Osaka F., et al. A new NEDD8-ligating system for cullin-4A.