Splicing factor U2AF 35 kDa subunit (U2AF1)

Plays a crucial role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point.

Directly mediates interactions between U2AF2 and proteins bound to the boosters and thus may be a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron. .