TSPO Antibodies

AND TSPO ELISA kits, TSPO Proteins

Many biological assays use antibodies to detect TSPO, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TSPO in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TSPO antibodies...

We validate the specificity of these antibodies to TSPO by testing them on tissues known to express TSPO positively and negatively. Browse below to find the TSPO antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TSPO Infographic by Boster Bio

All TSPO Products

Product

Figures

Specificity

Applications

Price

Anti-PBR TSPO Rabbit Monoclonal Antibody

2 Q&As

Human, Mouse

Flow Cytometry, IP, IF, IHC, ICC, WB

$370
Cat # M01153
100 μl

Anti-PBR TSPO Antibody

Human, Mouse, Rat

$405
Cat # A01153-1
100ul

TSPO Overview

Facts about Putative peripheral benzodiazepine receptor-related protein.

TSPO 3D structure. Source: alphafold

Putative peripheral benzodiazepine receptor-related protein (TSPO)

Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transfer of cholesterol across mitochondrial membranes and might play a role in lipid metabolism (PubMed:24814875), but its exact physiological function is controversial.

It's apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; may also bind isoquinoline carboxamides (PubMed:1847678).

Gene Information

Human
Gene Name:	TSPO
Uniprot:	B1AH88
Entrez:	706

Family

Belongs to:

No superfamily

Alternative Names

benzodiazepine peripheral binding site; BZRPDBI; IBP; MBRPBS; mDRC; Mitochondrial benzodiazepine receptor; PBR; PBRBPBS; PBRS; peripheral benzodiazepine receptor; Peripheral-type benzodiazepine receptor; pk18; PKBSbenzodiazapine receptor (peripheral); PTBR; translocator protein (18kDa); translocator protein; TSPO

Molecular Weight

Mass (kDA):
10.537 kDA

Genomic Context


Human

Location:	22q13.2
Sequence:	22; NC_000022.11 (43151559..43163242)

Tissue Specificity

Ubiquitous.

Diseases

Inflammation
Malignant Neoplasms
Neoplasms
Glioma
Brain Injuries
Anxiety Disorders
Neurodegenerative Disorders
Ischemia
Nervousness
Malignant Neoplasm Of Breast
Cerebrovascular Accident
Nerve Degeneration
Alzheimer's Disease

Brain Neoplasms
Mammary Neoplasms
Reperfusion Injury
Sclerosis
Encephalitis
Glioblastoma
Nervous System Disorder

Pathways

Transport
Cell Proliferation
Cell Death
Cholesterol Transport
Localization
Cell Growth
Regeneration
Cholesterol Import
Pathogenesis
Neuroprotection
Secretion
Inflammatory Response
Excretion

Autophagy
Gene Silencing
Cell Cycle
Induction Of Apoptosis
Methylation
Protein Import
Secretory Pathway

PTMs

Cleavage
Oxidation
Phosphorylation
Methylation

Nitrosylation
Hydroxylation
Dephosphorylation
Iodination

Research Areas

Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TSPO

References

PMID: 8307574 by Lin D., et al. The human peripheral benzodiazepine receptor gene: cloning and characterization of alternative splicing in normal tissues and in a patient with congenital lipoid adrenal hyperplasia.