Transcription factor EC Antibodies

AND Tfec ELISA kits, Transcription factor EC Proteins

Many biological assays use antibodies to detect Transcription factor EC, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Transcription factor EC in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Transcription factor EC antibodies...

We validate the specificity of these antibodies to Transcription factor EC by testing them on tissues known to express Tfec positively and negatively. Browse below to find the Tfec antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Tfec Infographic by Boster Bio

All Tfec Products

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Specificity

Applications

Price

Anti-TFEC Mouse Monoclonal Antibody [Clone ID: OTI1B4]

Human

$523
Cat # M07841
100 µl

TFEC (NM_001018058) Human Over-expression Lysate

Human

$628
Cat # LS022797
100 µg

Tfec Overview

Facts about Transcription factor EC.

Transcription factor EC (Tfec)

Transcriptional regulator that functions as a repressor or an activator. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter.

Collaborates with MITF in target gene activation. Acts as a transcriptional repressor on minimal promoter containing element F (which contains an E-box sequence) (By similarity).

Gene Information

Mouse
Gene Name:	Tfec
Uniprot:	Q9WTW4
Entrez:	21426

Family

Belongs to:

MiT/TFE family

Alternative Names

Class E basic helix-loop-helix protein 34; hTFEC-L; TCFECTFECLbHLHe34BHLHE34; TFE-C; transcription factor EC; Transcription factor EC-like

Molecular Weight

Mass (kDA):
35.144 kDA

Genomic Context


Mouse

Location:	6\|6 A2
Sequence:	6;

Tissue Specificity

Expressed in osteoclast-like cells (at protein level). Expressed in cells of the mononuclear phagocyte lineage. Expressed in macrophages and in osteoclast-like cells.

Diseases

Carcinoma
Neoplasms
Microphthalmos
Renal Cell Carcinoma
Malignant Neoplasms
Kidney Diseases
Injury To Kidney
Kidney Neoplasm
Sarcoma
Chromosomal Translocation
Melanoma
Mitochondrial Damage

Chondrosarcoma
Pathologic Neovascularization
Hepatotoxicity
Renal Tubular Necrosis
Waardenburg Syndrome
Alveolar Soft Part Sarcoma
Cell Transformation, Neoplastic

Pathways

Cell Death
Transport
Eye Development
Pigmentation
Transdifferentiation
Oncogenesis
Cell Development
Localization
Cell Growth
Osteoclast Development
Proteolysis
Organic Anion Transport
Pigment Cell Development

Vasculogenesis
Malate-aspartate Shuttle
Cellular Respiration
Mitochondrial Translocation
Translation
Cell Cycle
Cell Differentiation

PTMs

Cleavage
Phosphorylation

Oxidation
Acylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Tfec

References

PMID: 10036191 by Rehli M., et al. Cloning and characterization of the murine genes for bHLH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members.

PMID: 7958932 by Hemesath T.J., et al. microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family.