TDGF1 Antibodies

Teratocarcinoma-derived growth factor 1 (TDGF1)

GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis.

Shedding of TDGF1 by TMEM8A modulates Nodal signaling by enabling soluble TDGF1 to act as a Nodal coreceptor on other tissues (PubMed:27881714). Could play a role in the determination of the epiblastic cells which then give rise to the mesoderm (PubMed:11909953).

Gene Information

Human
Gene Name:	TDGF1
Uniprot:	P13385
Entrez:	6997

Family

Belongs to:
EGF-CFC (Cripto-1/FRL1/Cryptic) family

Alternative Names

CFC-2; CR; Cripto; Cripto-1 growth factor; Cripto-1; CRIPTOCRGF; Epidermal growth factor-like cripto protein CR1; TDGF1; TDGF-1; teratocarcinoma-derived growth factor 1

Molecular Weight

Mass (kDA):
21.169 kDA

Genomic Context

Human
Location:	3p21.31
Sequence:	3; NC_000003.12 (46574535..46582457)

Tissue Specificity

Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.

Subcellular Localizations

Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Released from the cell membrane by GPI cleavage.

Diseases

• Neoplasms
• Malignant Neoplasms
• Carcinoma
• Cell Transformation, Neoplastic
• Mammary Neoplasms
• Malignant Neoplasm Of Breast
• Cell Invasion
• Colonic Neoplasms
• Malignant Tumor Of Colon
• Cardio-facio-cutaneous Syndrome
• Malignant Paraganglionic Neoplasm
• Neoplasm Metastasis

• Embryonal Carcinoma
• Carcinogenesis
• Neoplasm Invasiveness
• Adenocarcinoma
• Metaplastic Cell Transformation
• Hyperplasia
• Tumor Angiogenesis

Pathways

• Cell Proliferation
• Cell Growth
• Gastrulation
• Mammary Gland Development
• Gland Development
• Pathogenesis
• Localization
• Angiogenesis
• Cell Migration
• Mesoderm Formation
• Embryo Development
• Cell Differentiation
• Lactation

• Oncogenesis
• Cell Cycle
• Dna Methylation
• Epithelial To Mesenchymal Transition
• Methylation
• Axis Specification
• Cell Death

PTMs

• Phosphorylation
• Cleavage
• Phosphorothioation
• Methylation

• Glycosylation
• Dephosphorylation
• Demethylation
• Farnesylation

• Gpi Anchoring

Research Areas

• Apoptosis
• Cancer
• Cellular Markers
• Neuroscience
• Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TDGF1

Boster Bio - Best Uses Of The TDGF1 Marker

This article will cover the history of Steven Boster. We'll also be discussing the uses of this product as well as what scientists should do. These results are applicable to scientists around the world. The next step in determining if this product is right is to evaluate the benefits. TDGF1 (the most important protein in the human body) is the next step.

History of Steven Boster

Steve Boster was a man who could turn science into a lavatory for many years. His first products came in the early 90s and included dozens of primary antibodies. He quickly became China’s most important catalog antibody manufacturer. By the late 90s, he had developed a proprietary ELISA platform called PicoKine. He used his trade secrets to create high-sensitivity ELISA kits.

Steve Boster was a Joliet resident. He was a retail salesman for many years. He was also a member of Concordia Hall of Staunton, VA. He is survived his son Jonathan and grandson Cory as well as his two daughters Crystal Boster and Natosha Pueck. He is also survived by his four siblings Jack Boster, Sandra Blanton, as well as Tammy, his sister.

TDGF1

TDGF1 belongs to the epidermal-growth factor (EGF), family. It regulates several pathways and controls cellular changes during embryonic stage. Although the role TDGF1 may play in colorectal tumors is not known, this gene can be used in a variety of clinical applications. We analyzed the TDGF1 gene expression in 55 colorectal cancer patients to determine its biological significance. To determine the biological significance of TDGF1 gene expression, we performed knockdown experiments.

Anti-Cripto TDGF1 Monoclonal Antibody

Cripto Monoclonal Antibody TDGF1 is available in several suppliers. This antibody targets the gene which encodes the protein known as teratocarcinoma-derived growth factor (Tdgf-1) whose structural mass is 21.2 kilodaltons. It may also have orthologs found in a range other species like mouse, monkey, and hybridoma.

This antibody is made with 17 amino acids derived form Human TDGF1. It is available in undiluted and diluted solutions. It can be stored at temperatures of 2-8 and 20 degrees Celsius for several weeks. The solution should not go through multiple freeze-thaw cycles. After it has been diluted, it should then be gently mixed before being used. The antibody solution should be used only for laboratory research, not as a drug.

Cripto binds to the protein GRP78, and the two interact at the cell surface. Their interaction occurs without any prior association in ER. Gray and colleagues claim that the Cripto-1/GRP78 complex works together to block the growth inhibitory effects TGF-b/Activins. GRP78 also enhances the activity of c-src/MAPK/Akt and increases cellular proliferation.

A peptide might interfere with Cripto-1/GRP78 interaction. Phage analysis of peptides within cells can identify peptides which interfere with the interaction Cripto-1/GRP78. Cripto-1 might also be bound to peptides which correspond to the N-20 Epitope of GRP78. These antibodies may be useful in diagnosing diseases.