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TXNRD1 Antibodies
AND TXNRD1 ELISA kits, TXNRD1 Proteins
Many biological assays use antibodies to detect TXNRD1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TXNRD1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TXNRD1 antibodies...
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TXNRD1 Infographic by Boster Bio
All TXNRD1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M01778
100 μl
Cat # M01778
100 μl
Enzyme Activity, SDS-PAGE
$243
Cat # PROTQ16881
Starting from 20ug
Cat # PROTQ16881
Starting from 20ug
TXNRD1 Overview
Facts about Thioredoxin reductase 1, cytoplasmic.
Thioredoxin reductase 1, cytoplasmic (TXNRD1)
Isoform 1 may have glutaredoxin activity in addition to thioredoxin reductase activity and induces actin and tubulin polymerization, resulting in formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only.
Isoform 5 also mediates cell death induced by a mixture of interferon-beta and retinoic acid. .
Gene Information
| Human | |
|---|---|
| Gene Name: | TXNRD1 |
| Uniprot: | Q16881 |
| Entrez: | 7296 |
Family
| Belongs to: |
|---|
| class-I pyridine nucleotide-disulfide oxidoreductase family |
Alternative Names
EC 1.8.1; EC 1.8.1.9; Gene associated with retinoic and IFN-induced mortality 12 protein; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM12; GRIM-12; GRIM-12TR1; KDRF; KM-102-derived reductase-like factor; MGC9145; oxidoreductase; Thioredoxin Reductase 1; thioredoxin reductase 1, cytoplasmic; thioredoxin reductase GRIM-12; Thioredoxin reductase TR1; TR; TR1; TRXR1; TRXRD1; TXNR; TXNRD1; TXNRTRXR1
Molecular Weight
Mass (kDA):
70.906 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q23.3 |
| Sequence: | 12; NC_000012.12 (104215779..104350307) |
Tissue Specificity
Isoform 1 is expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines. Isoform 4 is widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver.
Subcellular Localizations
Cytoplasm.; [Isoform 4]: Cytoplasm. Nucleus.; [Isoform 5]: Cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Mammary Neoplasms
- Carcinogenesis
- Cell Transformation, Neoplastic
- Liver Carcinoma
- Carcinoma
- Hepatocarcinogenesis
- Malignant Neoplasm Of Breast
- Liver Neoplasms, Experimental
- Adenocarcinoma
- Hyperplasia
Interacting Proteins
- CAV1
- ESR1
- ESR2
Pathways
- Cell Proliferation
- Cell Death
- Translation
- Cell Cycle
- Localization
- Response To Oxidative Stress
- Pathogenesis
- Transport
- Cell Growth
- Regeneration
- Dna Replication
- Aging
- Reverse Transcription
PTMs
- Reduction
- Phosphorylation
- Oxidation
Research Areas
- Breast Cancer
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TXNRD1
bosterbio.com/bosterbio-gene-info-cards/TXNRD1
References
PMID: 7589432 by Gasdaska P.Y., et al. Cloning and sequencing of a human thioredoxin reductase.
PMID: 8999974 by Koishi R., et al. Cloning and characterization of a novel oxidoreductase KDRF from a human bone marrow-derived stromal cell line KM-102.