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- Table of Contents
Facts about Tubulin beta-4A chain.
.
Human | |
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Gene Name: | TUBB4A |
Uniprot: | P04350 |
Entrez: | 10382 |
Belongs to: |
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tubulin family |
TUBB5beta-5; Tubulin 5 beta; tubulin beta-4 chain; tubulin, beta 4; tubulin, beta, 5
Mass (kDA):
49.586 kDA
Human | |
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Location: | 19p13.3 |
Sequence: | 19; NC_000019.10 (6494319..6502848, complement) |
Major isotype in brain, where it represents 46% of all beta-tubulins. In the brain, highest expression levels in the cerebellum, followed by putamen and white matter. Moderate levels in testis. Very low levels, if any, in other tissues.
Cytoplasm, cytoskeleton.
PMID: 6462917 by Lee M.G.-S., et al. Sequence of an expressed human beta-tubulin gene containing ten Alu family members.
PMID: 8619814 by Baumann M.H., et al. C-terminal fragments of alpha- and beta-tubulin form amyloid fibrils in vitro and associate with amyloid deposits of familial cerebral amyloid angiopathy, British type.