Tetraspanin-15 Antibodies

AND TSPAN15 ELISA kits, Tetraspanin-15 Proteins

Many biological assays use antibodies to detect Tetraspanin-15, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Tetraspanin-15 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Tetraspanin-15 antibodies...

We validate the specificity of these antibodies to Tetraspanin-15 by testing them on tissues known to express TSPAN15 positively and negatively. Browse below to find the TSPAN15 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TSPAN15 Infographic by Boster Bio

All TSPAN15 Products

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Product

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Specificity

Applications

Price

TSPAN15 (NM_012339) Human Recombinant Protein

$813
Cat # PROTO95858
20 µg

TSPAN15 (NM_012339) Human Over-expression Lysate

Human

$628
Cat # LS023555
100 µg

TSPAN15 Overview

Facts about Tetraspanin-15.

TSPAN15 3D structure. Source: alphafold

Tetraspanin-15 (TSPAN15)

Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Promotes ADAM10-mediated cleavage of CDH2.

Negatively regulates ligand-induced Notch activity likely by regulating ADAM10 activity. .

Gene Information

Human
Gene Name:	TSPAN15
Uniprot:	O95858
Entrez:	23555

Family

Belongs to:

tetraspanin (TM4SF) family

Alternative Names

NET7; NET-7; Tetraspan NET-7; tetraspanin 15,2700063A19Rik; TM4SF15; Transmembrane 4 superfamily member 15NET7tetraspanin-15; transmembrane 4 superfamily member tetraspan NET-7; TSPAN15; tspan-15

Molecular Weight

Mass (kDA):
33.165 kDA

Genomic Context


Human

Location:	10q22.1
Sequence:	10; NC_000010.11 (69451464..69549508)

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Late endosome membrane.

Diseases

Malignant Neoplasms
Inflammation
Alzheimer's Disease

Interacting Proteins

ADAM10
SYNE4

Pathways

Cell Migration
Oogenesis

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TSPAN15

References

PMID: 26686862 by Jouannet S., et al. TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization.

PMID: 30463011 by Shah J., et al. A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote alpha-Toxin Cytotoxicity.