Thyrotropin receptor Antibodies

AND TSHR ELISA kits, Thyrotropin receptor Proteins

Many biological assays use antibodies to detect Thyrotropin receptor, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Thyrotropin receptor in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Thyrotropin receptor antibodies...

We validate the specificity of these antibodies to Thyrotropin receptor by testing them on tissues known to express TSHR positively and negatively. Browse below to find the TSHR antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TSHR Infographic by Boster Bio

All TSHR Products

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Product

Figures

Specificity

Applications

Price

Anti-TSH Receptor/TSHR Antibody Picoband®

1 Citations 15 Q&As

Human, Mouse, Rat

$370
Cat # A00576-1
100 μg/vial

Anti-TSH-Receptor, B-Chain (Thyroid Marker) Monoclonal Antibody

15 Q&As

Human

Flow Cytometry, IF, IHC

$486
Cat # M00576
100ug/vial

Human Thyroid Stimulating Hormone (TSH) OneStep ELISA Kit

Human

ELISA

$369
Cat # EK7098
96 wells/kit

TSH Receptor (TSHR) (NM_000369) Human Over-expression Lysate

Human

$960
Cat # LS007253
100 µg

TSHR Overview

Facts about Thyrotropin receptor.

TSHR 3D structure. Source: alphafold

Thyrotropin receptor (TSHR)

Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:11847099, PubMed:12045258). Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258).

The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099). Plays a central role in controlling thyroid cell metabolism (By similarity).

Gene Information

Human
Gene Name:	TSHR
Uniprot:	P16473
Entrez:	7253

Family

Belongs to:

G-protein coupled receptor 1 family

Alternative Names

CHNG1; LGR3; LGR3hTSHR-I; MGC75129; seven transmembrane helix receptor; thyroid stimulating hormone receptor; Thyroid-stimulating hormone receptor; thyrotropin receptor; thyrotropin receptor-I, hTSHR-I; TSH R; TSHR; TSH-R

Molecular Weight

Mass (kDA):
86.83 kDA

Genomic Context


Human

Location:	14q31.1
Sequence:	14; NC_000014.9 (80954989..81146302)

Tissue Specificity

Expressed in thyroide cells (at protein level) (PubMed:11847099). Expressed in the thyroid (PubMed:2610690).

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.

Diseases

Graves Disease
Hyperthyroidism
Autoimmune Reaction
Hypothyroidism
Thyroid Diseases
Thyroid Neoplasm
Goiter
Hashimoto Disease
Autoimmune Diseases
Malignant Neoplasm Of Thyroid
Autoimmunity
Thyroiditis

Malignant Neoplasms
Neoplasms
Thyroid Associated Opthalmopathies
Carcinoma
Thyroid Nodule
Adenoma
Congenital Hypothyroidism

Interacting Proteins

ADORA1
MID1IP1
SCRIB
SYT1

Pathways

Pathogenesis
Secretion
Immune Response
Glycosylation
Cell Proliferation
Localization
Methylation
Cell Growth
Reverse Transcription
Cell Differentiation
Dedifferentiation
Hormone Secretion
Cytokine Production

Cell Death
Sulfation
Transport
Endocytosis
Bone Remodeling
Oncogenesis
Hatching

PTMs

Cleavage
Glycosylation
Phosphorylation
Methylation
Iodination
Deglycosylation
Demethylation
Biotinylation

Gpi Anchoring
Palmitoylation
Carboxylation
Deamination
Prenylation
Ribosylation
Ubiquitination
Reduction

Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TSHR

References

PMID: 2558651 by Nagayama Y., et al. Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor.

PMID: 2610690 by Libert F., et al. Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies.

1 Publications of Boster Thyrotropin receptor Antibodies & ELISA Kits

PubMed ID: 10.1111/asj.12883, Effects of hyper‐ and hypothyroidism on the development and proliferation of t...

*More publications can be found for each product on its corresponding product page