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- Table of Contents
Facts about Transformation/transcription domain-associated protein.
Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation.
Human | |
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Gene Name: | TRRAP |
Uniprot: | Q9Y4A5 |
Entrez: | 8295 |
Belongs to: |
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PI3/PI4-kinase family |
350/400 kDa PCAF-associated factor; FLJ10671; PAF350/400; PAF400; PAF400STAF40; STAF40; Tra1 homolog; Tra1; transformation/transcription domain-associated protein; TR-AP; TRRAP
Mass (kDA):
437.6 kDA
Human | |
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Location: | 7q22.1 |
Sequence: | 7; NC_000007.14 (98878490..99013243) |
Nucleus.
PMID: 9708738 by McMahon S.B., et al. The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins.
PMID: 9885574 by Vassilev A., et al. The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily.