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- Table of Contents
Facts about Zinc finger transcription factor Trps1.
Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the distinction of columnar into hypertrophic chondrocytes.
Human | |
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Gene Name: | TRPS1 |
Uniprot: | Q9UHF7 |
Entrez: | 7227 |
Belongs to: |
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No superfamily |
GC79; trichorhinophalangeal syndrome I; tricho-rhino-phalangeal syndrome type I protein; TRPS1
Mass (kDA):
141.521 kDA
Human | |
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Location: | 8q23.3 |
Sequence: | 8; NC_000008.11 (115408496..115668975, complement) |
Ubiquitously expressed in the adult. Found in fetal brain, lung, kidney, liver, spleen and thymus. More highly expressed in androgen-dependent than in androgen-independent prostate cancer cells.
Nucleus.
PMID: 10615131 by Momeni P., et al. Mutations in a new gene, encoding a zinc-finger protein, cause tricho-rhino-phalangeal syndrome type I.
PMID: 10974077 by Chang G.T.G., et al. Characterization of a zinc-finger protein and its association with apoptosis in prostate cancer cells.