Zinc finger protein RFP Antibodies

E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of'Lys-48'-linked polyubiquitin chains; the role inhibits CD4 T- cell regeneration. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of'Lys-63'-linked polyubiquitin chains at'Lys-220' of WASHC1, leading to encourage endosomal F-actin assembly (PubMed:23452853).

Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events.