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- Table of Contents
Facts about Transcription intermediary factor 1-alpha.
Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53.
Human | |
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Gene Name: | TRIM24 |
Uniprot: | O15164 |
Entrez: | 8805 |
Belongs to: |
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No superfamily |
E3 ubiquitin-protein ligase TRIM24; EC 6.3.2; EC 6.3.2.-; hTIF1; PTC6; RING finger protein 82; RNF82Tif1a; TIF1-alpha; TIF1ATIF1ALPHA; TIF1TF1A; transcription intermediary factor 1-alpha; transcriptional intermediary factor 1; tripartite motif containing 24; tripartite motif-containing 24; Tripartite motif-containing protein 24
Mass (kDA):
116.831 kDA
Human | |
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Location: | 7q33-q34 |
Sequence: | 7; NC_000007.14 (138460259..138589996) |
Nucleus. Cytoplasm. Colocalizes with sites of active transcription. Detected both in nucleus and cytoplasm in some breast cancer samples. Predominantly nuclear.
PMID: 9115274 by Thenot S., et al. Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1.
PMID: 10022127 by Venturini L., et al. TIF1gamma, a novel member of the transcriptional intermediary factor 1 family.