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TRAP1 Antibodies
AND TRAP1 ELISA kits, TRAP1 Proteins
Many biological assays use antibodies to detect TRAP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRAP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRAP1 antibodies...
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TRAP1 Infographic by Boster Bio
All TRAP1 Products
Product
Figures
Specificity
Applications
Price
Dog, Human, Monkey, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M02426
100 µl
Cat # M02426
100 µl
Dog, Human, Monkey, Mouse, Rat
IF, IHC, WB
$523
Cat # M02426-2
100 µl
Cat # M02426-2
100 µl
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A02426-1
100 μg/vial
Cat # A02426-1
100 μg/vial
TRAP1 Overview
Facts about Heat shock protein 75 kDa, mitochondrial.
Heat shock protein 75 kDa, mitochondrial (TRAP1)
Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I.
Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.
Gene Information
| Human | |
|---|---|
| Gene Name: | TRAP1 |
| Uniprot: | Q12931 |
| Entrez: | 10131 |
Family
| Belongs to: |
|---|
| heat shock protein 90 family |
Alternative Names
HSP 75; HSP75TNFR-associated protein 1; HSP90Lheat shock protein 75 kDa, mitochondrial; TNF receptor-associated protein 1; TRAP-1; tumor necrosis factor type 1 receptor associated protein; Tumor necrosis factor type 1 receptor-associated protein
Molecular Weight
Mass (kDA):
80.11 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p13.3 |
| Sequence: | 16; NC_000016.10 (3658037..3717524, complement) |
Tissue Specificity
Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is higly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors.
Subcellular Localizations
Mitochondrion. Mitochondrion inner membrane. Mitochondrion matrix.
Diseases
- Malignant Neoplasms
- Neoplasms
- Parkinson Disease
- Carcinoma
- Ovarian Neoplasm
- Adenocarcinoma
- Malignant Neoplasm Of Ovary
- Colorectal Cancer
- Tissue Adhesions
- Hypoxia
- Secondary Parkinson Disease
- Neoplasm Metastasis
Interacting Proteins
- HSD17B10
Pathways
- Cell Death
- Localization
- Pathogenesis
- Cell Cycle
- Drug Resistance
- Cell Adhesion
- Cell Proliferation
- Response To Heat
- Release Of Cytochrome C From Mitochondria
- Induction Of Apoptosis
- Mitosis
- Dna Repair
- Cell Growth
PTMs
- Phosphorylation
- Cleavage
Research Areas
- Membrane Trafficking and Chaperones
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRAP1
bosterbio.com/bosterbio-gene-info-cards/TRAP1
References
PMID: 10545594 by Simmons A.D., et al. A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses.
PMID: 7876093 by Song H.Y., et al. Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor.
1 Publications of Boster TRAP1 Antibodies & ELISA Kits
- PubMed ID: 32815169, Yu F,Li BY,Yin M,Lu WD,Li XL,Cheng M,Gao HQ.Proteomic analysis of liver mitochon...
*More publications can be found for each product on its corresponding product page