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TRAIP Antibodies
AND TRAIP ELISA kits, TRAIP Proteins
Many biological assays use antibodies to detect TRAIP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRAIP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRAIP antibodies...
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TRAIP Infographic by Boster Bio
All TRAIP Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IHC, WB
$523
Cat # M07953
100 µl
Cat # M07953
100 µl
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A07953-2
100 μg/vial
Cat # A07953-2
100 μg/vial
TRAIP Overview
Facts about E3 ubiquitin-protein ligase TRAIP.
E3 ubiquitin-protein ligase TRAIP (TRAIP)
Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and following IFNB1 production and cellular antiviral response by boosting'Lys-48'-linked polyubiquitination of TNK1 resulting in its proteasomal degradation (By similarity) (PubMed:22945920).
Involved in response to genotoxic lesions during genome replication. Promotes H2AX and RPA2 phosphorylation following replication-associated DNA damage and aids fork progression at UV-induced replication-blocking lesions during S phase (PubMed:26595769).
Gene Information
| Human | |
|---|---|
| Gene Name: | TRAIP |
| Uniprot: | Q9BWF2 |
| Entrez: | 10293 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
RNF206TRIPRING finger protein 206; TRAF interacting protein; TRAF-interacting protein
Molecular Weight
Mass (kDA):
53.294 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p21.31 |
| Sequence: | 3; NC_000003.12 (49828595..49856584, complement) |
Subcellular Localizations
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Nucleus, nucleolus. In the nucleus, found in close proximity to PCNA, suggesting localization at replication foci. After UV irradiation, rapidly localizes to sites of DNA damage, where it colocalizes with phosphorylated histone H2AX (gamma-H2AX) and RPA2.
Diseases
- Ulcerative Colitis
- Ulcer
- Basal Cell Carcinoma
- Skin Neoplasms
- Crohn Disease
- Hyperplasia
- Growth Arrest
- Dysequilibrium Syndrome
Interacting Proteins
- MAPRE2
- NCK1
Pathways
- Cell Cycle
- Dna Ligation
- Regulation Of Cell Cycle
- Cell Proliferation
- Cell Death
- Keratinocyte Proliferation
- Regulation Of Cell Proliferation
- Pathogenesis
PTMs
Research Areas
- Zinc Finger
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRAIP
bosterbio.com/bosterbio-gene-info-cards/TRAIP
References
PMID: 9104814 by Lee S.Y., et al. TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation.
PMID: 14676304 by Regamey A., et al. The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor.