TPRKB Antibodies

AND TPRKB ELISA kits, TPRKB Proteins

Many biological assays use antibodies to detect TPRKB, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TPRKB in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TPRKB antibodies...

We validate the specificity of these antibodies to TPRKB by testing them on tissues known to express TPRKB positively and negatively. Browse below to find the TPRKB antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TPRKB Infographic by Boster Bio

All TPRKB Products

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Specificity

Applications

Price

TPRKB (NM_016058) Human Recombinant Protein

$813
Cat # PROTQ9Y3C4
20 µg

Anti-TPRKB Mouse Monoclonal Antibody [Clone ID: OTI3H3]

+13

Human, Monkey, Mouse

Flow Cytometry, IF, IHC, WB

$523
Cat # M10528
100 µl

TPRKB (NM_016058) Human Over-expression Lysate

Human

$628
Cat # LS051002
100 µg

TPRKB Overview

Facts about EKC/KEOPS complex subunit TPRKB.

TPRKB 3D structure. Source: alphafold

EKC/KEOPS complex subunit TPRKB (TPRKB)

Component of the EKC/KEOPS complex that is necessary for the creation of a threonylcarbamoyl set on adenosine at position 37 (t(6)A37) in tRNAs that read codons starting with adenine (PubMed:22912744, PubMed:28805828). The complex is probably involved in the transport of this threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 set of A37 (PubMed:22912744, PubMed:28805828).

TPRKB acts as an allosteric effector that modulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification (PubMed:22912744, PubMed:28805828).

Gene Information

Human
Gene Name:	TPRKB
Uniprot:	Q9Y3C4
Entrez:	51002

Family

Belongs to:

CGI121/TPRKB family

Alternative Names

CGI-121; PRPK (p53-related protein kinase)-binding protein; PRPK-binding protein; TP53RK binding protein; TP53RK-binding protein

Molecular Weight

Mass (kDA):
19.661 kDA

Genomic Context


Human

Location:	2p13.1
Sequence:	2; NC_000002.12 (73729837..73737406, complement)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Cytoplasm, cytosol. Nucleus.

Interacting Proteins

TP53RK
TRIM27

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TPRKB

References

PMID: 12659830 by Miyoshi A., et al. Identification of CGI-121, a novel PRPK (p53-related protein kinase)- binding protein.

PMID: 22912744 by Costessi A., et al. The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME.