Nucleoprotein TPR Antibodies

Nucleoprotein TPR (TPR)

Functions as a scaffolding component in the atomic stage of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species posture constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner.

Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Doesn't play any role in Rev response element (RRE)-mediated export of unspliced mRNAs.

Gene Information

Human
Gene Name:	TPR
Uniprot:	P12270
Entrez:	7175

Family

Belongs to:
TPR family

Alternative Names

nuclear pore complex-associated protein TPR; nucleoprotein TPR; translocated promoter region (to activated MET oncogene); tumor potentiating region

Molecular Weight

Mass (kDA):
267.293 kDA

Genomic Context

Human
Location:	1q31.1
Sequence:	1; NC_000001.11 (186311652..186375253, complement)

Tissue Specificity

Expressed in esophagus, ovary, liver, skin, smooth muscles, cerebrum and fetal cerebellum (at protein level). Highest in testis, lung, thymus, spleen and brain, lower levels in heart, liver and kidney.

Subcellular Localizations

Nucleus. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Nucleus envelope. Nucleus, nuclear pore complex. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Detected as discrete intranuclear foci with IFI204 (By similarity). In interphase, localizes to the nucleoplasmic side of the nuclear pore complex (NPC) core structure, forming a fibrous structure called the nuclear basket. Detected exclusively to the cytoplasmic margin of NPC (PubMed:7798308). Docking to the inner nucleoplasm

Diseases

• Cerebrovascular Accident
• Hypertensive Disease
• Pathologic Vasoconstriction
• Hypotension Adverse Event
• Essential Hypertension
• Heart Failure
• Neoplasms
• Malignant Neoplasms
• Nervousness
• Pulmonary Hypertension
• Bradycardia
• Stenosis

• Hypertrophy
• Depressive Disorder
• Stress, Psychological
• Hypoxia
• Hemorrhage
• Cardiovascular Diseases

Interacting Proteins

• MAD1L1

Pathways

• Vasoconstriction
• Reflex
• Vasodilation
• Localization
• Transport
• Cell Cycle
• Excretion
• Mitosis
• Glomerular Filtration
• Pathogenesis
• Cell Division
• Anaphase
• Translation

• Secretion
• Aging
• Nuclear Import
• Virulence
• Protein Folding
• Diuresis
• Interphase

PTMs

• Phosphorylation
• Oxidation
• Ubiquitination
• Cleavage
• Reduction
• Dephosphorylation
• Nitration
• Methylation

• Sumoylation
• Carboxylation
• Glycosylation
• Myristoylation
• Demethylation
• Deamination
• Hydroxylation
• Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TPR

Best Uses Of The TPR Marker

TPR markers are a great tool to measure the expression of a specific chemical in a cell line. The marker can also be used for species-specific purposes. Regardless of the application scientists can submit the results from experiments using this product to be eligible for product credits and receive special treatment. This marker is accessible to all scientists, regardless of where they are located. Learn more about its advantages and its features.

Nucleoprotein TPR Marker

Biological tests that test for the Nucleoprotein TPR protein often use antibodies against this protein. These antibodies are either monoclonal or polyclonal and react with Nucleoprotein TPR in a variety samples. These antibodies were made with mouse and rabbit as model animals. Boster Bio makes use of antibodies to detect Nucleoprotein (TPR) in different animal specimens.

TNR Marker

The TNR Marker is employed extensively in research, especially in molecular biology. The TNR Marker can be used to monitor changes in the populations of pest animals. Boster Bio has designed highly specific antibodies for this purpose and is backed by more than 25 years of research. The antibodies are validated in multiple methods, including Western Blotting, Immunohistochemistry, and ELISA.

TNR advocates use TNR markers for a variety of reasons that include saving cats as well as protecting wildlife habitat. They say that neutering cats decreases the risk of spreading disease as well as interspecific fighting and the vacuum effect. They also argue that returning neutered cats back to their natural habitats can reduce the number of cats that are in shelters and other places of the practice of euthanasia. TNR is a great method of controlling population, but is it really effective? It is most effective when the population is small and the feral cats do not become an issue.

While it is not possible to recognize every ailment present in the TNR cat, a poor physical health is more readily identifiable. In San Paolo, Brazil, 21% of strays were overweight and blind. Botany, Australia has more than 25% of cats who are blind or underweight.

Benefits of using the TPR Marker

TPR can be used by teachers to increase engagement in English lessons. The use of the TPR marker helps students to be more active and engaged, which boosts their energy levels. Children are more active and engaged than adults. Teachers can prevent children from exuberant energy by getting them moving. Students who copy from the teacher will feel more satisfied about their work. There is no need for students to perform in front of the entire class, which could be a huge benefit for students who struggle.

TPR is also a proven method for language acquisition. Regardless of the language level of your students, physical movements get across meanings easily. It aids students in applying the target language. TPR does not require a lot of preparation. Teachers can also easily modify it to meet the needs of their class. There are a few advantages of using TPR markers in teaching. For instance, you could use it in a classroom setting with students of different abilities.

TPR lets you use gestures to learn new vocabulary. This means that students are fully engaged in the learning. It also helps improve memory, which is important for learning a new language. Repetitive movements of the TPR can also enhance memory. TPR markers can also be used to help drill vocabulary. TPR has its own drawbacks. It is not recommended for all classes. In certain situations, students may be not able to learn new vocabulary.

TPR is based upon action verbs and can be used to teach specific verbs. TPR can be used to learn the "Cha Cha Slide" or "Superman" verbs as well as the more general ones. TPR can also teach the meaning of a new word. It is therefore best for students who are just beginning their studies. TPR can be used for prolonged periods of time when you find it difficult to sit still.

When it is used during circle time, TPR is effective. In this situation, students are sitting in a circle and have a good view of the teacher. The teacher will show the word and introduce an action. The teacher will then show the word and introduce an action. Students will then repeat the actions. Children will gain more vocabulary if TPR is used as an exercise. TPR can be utilized in virtual classrooms. You can modify the TPR method to meet your needs and those of your students.

Another benefit of TPR is that it can be used to teach nouns. TPR works best when nouns have clear actions. Examples of nouns that work best with TPR are football, bananas, and toothache. Other nouns, like banana as well as football, swimming, and are not taught in TPR. Nouns like football, swimming, and bananas can be taught in the same way as verbs.