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Nucleoprotein TPR Antibodies
AND TPR ELISA kits, Nucleoprotein TPR Proteins
Many biological assays use antibodies to detect Nucleoprotein TPR, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Nucleoprotein TPR in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Nucleoprotein TPR antibodies...
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TPR Infographic by Boster Bio
All TPR Products
Product
Figures
Specificity
Applications
Price
Anti-TPR Antibody Picoband®
6 Q&As
Human, Mouse, Rat
Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # A00695-1
100 μg/vial
Cat # A00695-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00695-2
100 μg/vial
Cat # A00695-2
100 μg/vial
TPR Overview
Facts about Nucleoprotein TPR.
Nucleoprotein TPR (TPR)
Functions as a scaffolding component in the atomic stage of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species posture constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner.
Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Doesn't play any role in Rev response element (RRE)-mediated export of unspliced mRNAs.
Gene Information
| Human | |
|---|---|
| Gene Name: | TPR |
| Uniprot: | P12270 |
| Entrez: | 7175 |
Family
| Belongs to: |
|---|
| TPR family |
Alternative Names
nuclear pore complex-associated protein TPR; nucleoprotein TPR; translocated promoter region (to activated MET oncogene); tumor potentiating region
Molecular Weight
Mass (kDA):
267.293 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q31.1 |
| Sequence: | 1; NC_000001.11 (186311652..186375253, complement) |
Tissue Specificity
Expressed in esophagus, ovary, liver, skin, smooth muscles, cerebrum and fetal cerebellum (at protein level). Highest in testis, lung, thymus, spleen and brain, lower levels in heart, liver and kidney.
Subcellular Localizations
Nucleus. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Nucleus envelope. Nucleus, nuclear pore complex. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Detected as discrete intranuclear foci with IFI204 (By similarity). In interphase, localizes to the nucleoplasmic side of the nuclear pore complex (NPC) core structure, forming a fibrous structure called the nuclear basket. Detected exclusively to the cytoplasmic margin of NPC (PubMed:7798308). Docking to the inner nucleoplasm
Diseases
- Cerebrovascular Accident
- Hypertensive Disease
- Pathologic Vasoconstriction
- Hypotension Adverse Event
- Essential Hypertension
- Heart Failure
- Neoplasms
- Malignant Neoplasms
- Nervousness
- Pulmonary Hypertension
- Bradycardia
- Stenosis
Interacting Proteins
- MAD1L1
Pathways
- Vasoconstriction
- Reflex
- Vasodilation
- Localization
- Transport
- Cell Cycle
- Excretion
- Mitosis
- Glomerular Filtration
- Pathogenesis
- Cell Division
- Anaphase
- Translation
PTMs
- Phosphorylation
- Oxidation
- Ubiquitination
- Cleavage
- Reduction
- Dephosphorylation
- Nitration
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TPR
bosterbio.com/bosterbio-gene-info-cards/TPR
References
PMID: 1549355 by Mitchell P.J., et al. Nucleotide sequence analysis of human tpr cDNA clones.
PMID: 1437155 by Mitchell P.J., et al. The human tpr gene encodes a protein of 2094 amino acids that has extensive coiled-coil regions and an acidic C-terminal domain.