TPPP Antibodies

AND TPPP ELISA kits, TPPP Proteins

Many biological assays use antibodies to detect TPPP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TPPP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TPPP antibodies...

We validate the specificity of these antibodies to TPPP by testing them on tissues known to express TPPP positively and negatively. Browse below to find the TPPP antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TPPP Infographic by Boster Bio

All TPPP Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

TPPP Tubulin Polymerization Promoting Protein Human Recombinant Protein

Human

$250
Cat # PROTO94811
2ug, 10ug, 1mg

Anti-TPPP Antibody

Human, Mouse, Rat

$405
Cat # A04389
100ul

Anti-TPPP Rabbit Monoclonal Antibody

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M04389-1
100 μl/vial

Tubulin Polymerization Promoting Protein (TPPP) (NM_007030) Human Over-expression Lysate

Human

$628
Cat # LS011076
100 µg

Anti-TPPP Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A04389-2
100 μg/vial

TPPP Overview

Facts about Tubulin polymerization-promoting protein.

TPPP 3D structure. Source: alphafold

Tubulin polymerization-promoting protein (TPPP)

May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.

Gene Information

Human
Gene Name:	TPPP
Uniprot:	O94811
Entrez:	11076

Family

Belongs to:

TPPP family

Alternative Names

p24; P24,25 kDa brain-specific protein; p25; p25alpha; p25-alpha; TPPP/p25brain specific protein p25 alpha; TPPP1glycogen synthase kinase 3 (GSK3) inhibitor p24; tubulin polymerization promoting protein; tubulin polymerization-promoting protein

Molecular Weight

Mass (kDA):
23.694 kDA

Genomic Context


Human

Location:	5p15.33
Sequence:	5; NC_000005.10 (659862..700727, complement)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Postsynaptic Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm, cytoskeleton. Nucleus. Cytoplasm, cytoskeleton, spindle. Specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation (By similarity). Mainly localizes to the cytoskeleton (PubMed:18028908). Also found in the nucleus; however, nuclear localization is unclear and requires additional evidences (PubMed:18028908). Localizes to glial Lewy bodies in the brains of individuals wit

Diseases

Atrophy
Multiple System Atrophy
Neurodegenerative Disorders
Parkinson Disease
Nervousness
Sclerosis
Malignant Neoplasms
Neoplasms
Alzheimer's Disease
Demyelinating Diseases
Lewy Body Disease
Gliosis
Cns Disorder

Neuroblastoma
Nerve Degeneration
Multiple Sclerosis
Nervous System Disorder
Prion Diseases
Disease Of Adrenal Medulla
Non-neoplastic Disorder

Interacting Proteins

HIST1H1A
SNCA

Pathways

Mitosis
Pathogenesis
Cell Death
Cell Proliferation
Myelination
Cell Division
Cell Differentiation
Transport
Tubulin Deacetylation
Astral Microtubule Organization
Chromosome Segregation
Cell Cycle Arrest
Microtubule Nucleation

Cell Motility
Cell Cycle
Cell Growth
Microtubule Polymerization
Rna Interference
Oligodendrocyte Differentiation
Spindle Assembly

PTMs

Phosphorylation
Cleavage
Ubiquitination

Deacetylation
Glycosylation
Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TPPP

References

PMID: 10083737 by Seki N., et al. A novel human gene whose product shares significant homology with the bovine brain-specific protein p25 on chromosome 5p15.3.

PMID: 15590652 by Lindersson E., et al. p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies.