Tripeptidyl-peptidase 1 Antibodies

AND TPP1 ELISA kits, Tripeptidyl-peptidase 1 Proteins

Many biological assays use antibodies to detect Tripeptidyl-peptidase 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Tripeptidyl-peptidase 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Tripeptidyl-peptidase 1 antibodies...

We validate the specificity of these antibodies to Tripeptidyl-peptidase 1 by testing them on tissues known to express TPP1 positively and negatively. Browse below to find the TPP1 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TPP1 Infographic by Boster Bio

All TPP1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-TPP1 Antibody Picoband®

6 Q&As

Human

IHC, WB

$370
Cat # PB9899
100 μg/vial

Human TPP1/Tripeptidyl-peptidase 1 ELISA Kit PicoKine®

10 Q&As

Human

ELISA

$499
Cat # EK2042
96 wells/kit, with removable strips.

Anti-Tripeptidyl-peptidase 1 TPP1 Antibody

Human, Mouse

$405
Cat # A01489
100ul

Anti-Tripeptidyl-peptidase 1 TPP1 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A01489-1
100ul

TPP1 (NM_000391) Human Over-expression Lysate

Human

$628
Cat # LS001200
100 µg

TPP1 Overview

Facts about Tripeptidyl-peptidase 1.

TPP1 3D structure. Source: alphafold

Tripeptidyl-peptidase 1 (TPP1)

Lysosomal serine protease with tripeptidyl-peptidase I action. May act as a non invasive lysosomal peptidase which generates tripeptides from the breakdown products created by lysosomal proteinases.

Requires substrates having an unsubstituted N-terminus (By similarity). .

Gene Information

Human
Gene Name:	TPP1
Uniprot:	O14773
Entrez:	1200

Family

Belongs to:

No superfamily

Alternative Names

Cell growth-inhibiting gene 1 protein; ceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-Bielschowsky disease); CLN2; CLN2EC 3.4.14.9; growth-inhibiting protein 1; LINCL; LPIC; lysosomal pepstatin insensitive protease; Lysosomal pepstatin-insensitive protease; MGC21297; TPP1; TPP-1; TPP-I; Tripeptidyl aminopeptidase; tripeptidyl peptidase I; tripeptidyl-peptidase 1; TripeptidylPeptidase I; Tripeptidyl-Peptidase I

Molecular Weight

Mass (kDA):
61.248 kDA

Genomic Context


Human

Location:	11p15.4
Sequence:	11; NC_000011.10 (6612768..6619422, complement)

Tissue Specificity

Detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues.

Subcellular Localizations

Lysosome. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Diseases

Neuronal Ceroid-lipofuscinoses
Late-infantile Neuronal Ceroid Lipfuscinosis
Malignant Neoplasms
Infantile Neuronal Ceroid Lipofuscinosis
Neurodegenerative Disorders
Neoplasms
Nerve Degeneration
Telomere Shortening
Nervousness
Lysosomal Storage Diseases
Blind Vision
Ataxia

Cytogenetic Abnormality
Genomic Instability
Epilepsy
Dysplasia
Visual Impairment
Atrophy

Interacting Proteins

STN1
TERT

Pathways

Telomere Maintenance
Pathogenesis
Localization
Dna Repair
Senescence
S Phase
Cell Cycle
Telomere Binding
Rna Interference
Transport
Aging
Segmentation
Telosome Assembly

Cell Death
Cell Growth
Single-stranded Dna Binding
Secretion
Hair Follicle Morphogenesis
Cellular Senescence
Immune Response

PTMs

Cleavage
Glycosylation
Oxidation

Deglycosylation
Phosphorylation
Dephosphorylation

Research Areas

Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TPP1

References

PMID: 9295267 by Sleat D.E., et al. Association of mutations in a lysosomal protein with classical late- infantile neuronal ceroid lipofuscinosis.

PMID: 9653647 by Liu C.-G., et al. Structural organization and sequence of CLN2, the defective gene in classical late infantile neuronal ceroid lipofuscinosis.